Calorie Restriction Mimetic Formula 60 veg. caps.

Scientists have intensely focused on finding out how calorie restriction so radically extends life span. In response to reduced calorie intake, beneficial “youth” genes are activated while detrimental “senescence” genes are disabled. These favorable gene expression changes play a critical role in the ability of calorie restriction to slow aging.

The good news is that a select group of nutrients has been discovered that trigger many of the same favorable mechanisms (including more youthful gene expression patterns) as caloric restriction. Among the most promising caloric restriction mimics and enhancers are resveratrol, pterostilbene, quercetin, and grape seed polyphenols, along with black tea extract. These nutrients have been shown to generate many of the same effects in the body as caloric restriction, without significant dietary modification.1-8 In particular, they help mimic caloric restriction’s favorable impact on genes that influence the aging process.1-8

Calorie Restriction Mimetic Formula includes resveratrol, pterostilbene, quercetin, grape seed polyphenols, and black tea extract to provide even broader spectrum gene expression support in one nutritional compound.

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

References
1. Cell. 2006 Dec 15;127(6):1109-22.
2. Endocrinology. 2008 Jan;149(1):84-92.
3. Crit Care Med. 2004 Oct;32(10):2097-103.
4. J Agric Food Chem. 1999 Apr;47(4):1416-21.
5. Arch Pharm Res. 2002 Oct;25(5):561-71.
6. Nutr Cancer. 1999;35(1):80-6.
7. Anticancer Agents Med Chem. 2006 Sep;6(5):389-406.
8. Nature. 2006 Nov 16;444(7117):337-42.

Printed with permission of Life Extension www.lef.org.

Serving size: 2 capsules Servings Per Container: 30
Amount per serving
Trans-Resveratrol [from Polygonum cuspidatum (root) extract]	250 mg
Trans-Pterostilbene (as pure Pterospan™ and SMART™† pterostilbene)	3 mg
Quercetin (from quercetin dihydrate)	150 mg
MASQUELIER’s® Original OPCs [single and condensed (2-5) units of flavanols & polyphenols from Vitis vinifera (grape) seeds]	50 mg
Black tea (Camellia sinensis) extract (leaf) [standardized to 12% TF2a theaflavin fraction (36 mg), along with TF1, TF2b and TF3 theaflavin fractions]	300 mg
Other ingredients: vegetable cellulose (capsule), stearic acid, silica, vegetable stearate.

† Same material as research trials.
Pterospan™ (Pure Pterostilbene) and SMART™ are trademarks of Pharma Science Nutrients, Inc., and are used here under license. All rights reserved worldwide.
MASQUELIER’s® is a registered trademark of International Nutrition Company BV (INC), Loosdrecht, The Netherlands.

Dosage and Use

Take 2 capsules daily, with or without food, or as recommended by a healthcare provider.
Can be take together or in divided doses
Calorie Restriction Mimetic Formula has less than 9 mg of caffeine per serving (the amount found in less than 1/4 cup of brewed green tea).

Caution

Consult with your doctor before using this product if you have a bleeding disorder, or if you are taking anticoagulant or antiplatelet medications, or diabetic medications.

This page was last modified on Friday December 30, 2011