TMG Tablets, 500 mg., 180 tablets
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TMG Tablets, 500 mg., 180 tablets |
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LE359 $13.50
TMG is also called glycine betaine, but the name “trimethylglycine” signifies that it has three methyl groups attached to each molecule of glycine. Betaine was discovered to be beneficial to heart health back in the 1950s.1-5 TMG operates along a different pathway than the B vitamins. TMG acts as a “methyl donor,” providing extra methyl groups to hasten the conversion of homocysteine back to methionine.6 When a TMG methyl group is donated to a molecule of homocysteine, it converts to the non-toxic amino acid, methionine, and then into S-adenosyl-methionine (SAMe).7,8 Research showing TMG’s ability to promote healthy levels of homocysteine, alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular health.9-17 For example, in a recent cross-sectional survey study, participants who consumed >360 mg/d of betaine had, on average, 10% lower concentrations of homocysteine and 19% lower concentrations of C-reactive protein than did those who consumed <260 mg/d.18 TMG (trimethylglycine) may be one of the most important nutrients to prevent heart disease, stroke, liver disease and to slow aging. In the body, TMG donates one of its methyl groups to cellular DNA, which may help protect DNA against damage and its consequences, cancer and premature aging. No “safe” level of homocysteine has been established, suggesting that taking nutrients like TMG could lower the risk of heart attack and stroke, in addition to protecting DNA. When people are methyl deficient, they are at a greater risk of developing cancer, cardiovascular disease, depression and a variety of neurological and other disorders. Methyl deficiency is characterized by too little s-adenosylmethionine, too much homocysteine or a loss of DNA methylation. SAMe is our chief methyl donor and is used for most methylation in our cells. Methylating enzymes use SAMe but are inhibited by metabolic products related to homocysteine. The buildup of homocysteine leads to inhibition of methylation reactions and can also cause cardiovascular disease. DNA methylation is absolutely essential for mammalian development and is a key mechanism in aging and carcinogenesis. Methyl metabolism is dependent on the dietary intake of nutrients such as vitamin B12, folate, choline, trimethylglycine (TMG) and zinc. It is imperative that we get enough methyl donors and methyl cofactors as DNA methylation levels generally decrease during aging and homocysteine levels rise with age in humans.
This product contains NO soybeans, milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO artificial sweeteners, flavors, colors, or preservatives. Caution: If muscle tension or headaches occur, reduce dosage.
Printed with permission of Life Extension www.lef.org. References 1. Ann West Med
Surg. 1951;5:825-9. Warning: These products are not intended to diagnose, treat, cure or prevent any disease. Please consult with a healthcare professional before starting any diet or exercise program. Some of these products are not recommended for individuals under the age of 18. | ||||||||||||||||||||||
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This page was last modified on Friday December 30, 2011 |
