TMG Tablets, 500 mg., 180 tablets

TMG (trimethylglycine) may be one of the most important nutrients to prevent heart disease, stroke, liver disease and to slow aging. TMG is also called glycine betaine, but the name “trimethylglycine” signifies that it has three methyl groups attached to each molecule of glycine. In the body, TMG donates one of its methyl groups to cellular DNA, which may help protect DNA against damage and its consequences, cancer and premature aging.

When a TMG methyl group is donated to a molecule of homocysteine, it is converted first to methionine then to S-adenosyl-methionine (SAMe). No “safe” level of homocysteine has been established, suggesting that taking nutrients like TMG could lower the risk of heart attack and stroke, in addition to protecting DNA.

When people are methyl deficient, they are at much greater risk of developing cancer, cardiovascular disease, depression and a variety of neurological and other disorders. Methyl deficiency is characterized by too little s-adenosylmethionine, too much homocysteine or a loss of DNA methylation. SAMe is our chief methyl donor and is used for most methylation in our cells. Methylating enzymes use SAMe but are inhibited by metabolic products related to homocysteine. The buildup of homocysteine leads to inhibition of methylation reactions and can also cause cardiovascular disease. DNA methylation is absolutely essential for mammalian development and is a key mechanism in aging and carcinogenesis.

Methyl metabolism is dependent on the dietary intake of nutrients such as vitamin B12, folate, choline, trimethylglycine (TMG) and zinc. It is imperative that we get enough methyl donors and methyl cofactors as DNA methylation levels generally decrease during aging and homocysteine levels rise with age in humans.

Caution:

If muscle tension or headaches occur, reduce dosage.

2 tablets contain

TMG (trimethylglycine) also called betaine glycine: 1000 mg

Other ingredients: Dicalcium phosphate, cellulose, stearic acid, magnesium stearate, croscarmellose sodium, silica and vegetable protein.

Dosage and use
Two tablets every morning.

Up to twelve tablets daily may be taken under the care of a physician to treat liver failure or depression.

TMG should be taken with co-factor vitamins B6 and B12, and folic acid.

Warning: These products are not intended to diagnose, treat, cure or prevent any disease. Please consult with a healthcare professional before starting any diet or exercise program. Some of these products are not recommended for individuals under the age of 18.

This page was last modified on Wednesday July 30, 2008