Indole-3-Carbinol with Standardized Broccoli Extract, 200 mg. 60 caps.

Indole-3-Carbinol is a plant compound from cruciferous vegetables, such as broccoli cauliflower, and cabbage, that has shown impressive results in maintaining healthy cell growth. Broccoli contains several compounds that help maintain healthy DNA function. The broad-spectrum benefits of cruciferous vegetables have now been combined into one capsule. The proprietary 3:1 blend of broccoli sprout concentrate provides sulforaphane for immediate absorption and glucosinolates, which must be broken down in the body to provide a broad spectrum of isothiocyanates.

Unlike other products on the market that contain only the isothiocyanate sulforaphane, I3C with Standarized Broccoli contains standardized levels of glucosinolates. Glucosinolates are precursors or the “parent” compound that include a natural spectrum of isothiocyanates. Glucosinolates are sulfur-containing phytonutrients, which are part of the genus Brassicaceae. It has been estimated that there are over 120 different glucosinolates known to exist in nature. Epidemiological (population) studies have demonstrated that glucosinolates found in these vegetables have health benefits and show supporting effects in maintaining healthy cells in the stomach, lung, and colon.

Indole-3-carbinol shows great potential in preventing cancer, especially hormone-related cancers such as breast and prostate. Now available as a supplement, I3C is hugely popular both as an antioxidant and as a cancer fighter. Research on I3C dates to the 1960s when it was investigated for its actions against chemical carcinogens. Since that time, researchers have been able to show that I3C has powerful and diverse ways of stopping cancer. While the break-down products of I3C may act unpredictably by themselves, when taken as I3C they are beneficial for preventing, and possibly treating, hormone-related cancers. The data is so compelling, it has provoked normally reserved researchers into such praise as, ³I3C has tremendous potential in the treatment and prevention of cancer, particularly estrogen-enhanced cancer.² (Meng Q, et al. 2000. J Nutr 130:2927-31) Although that comment was directed towards I3C¹s estrogen-blocking potential, I3C has equally important actions against all types of cancer.

A summary of recent studies shows that this vegetable extract:

Increases the conversion of estradiol to “weaker” (2OHE) estrogen, which has been shown to reduce breast cancer incidence
Works in estrogen receptor negative breast cancer cells.
Stops human cancer cells from growing (54-61%) and provokes the cells to self-destruct (apoptosis).
Inhibits MCF7 human breast cancer cells better than tamoxifen under laboratory conditions.
Protects against the environmental toxin, dioxin.
Restores p21 tumor suppressor gene.
Provides antioxidant protection.

Supplement Facts

Serving size 1 capsule
Servings per container 60
Amount per serving
Indole-3-Carbinol	200 mg
Broccoli sprout concentrate (Brassica oleracea) [standardized for 0.3% sulforaphane (0.45 mg), 1% total glucosinolates (1.5 mg)]	150 mg
Other ingredients: rice flour, gelatin, magnesium stearate, titanium dioxide.

Dosage and Use

Take one capsule per day for individuals weighing up to 179 pounds.
Those weighing over 239 pounds, take two capsules per day.
Can be take with or without food.

Warnings

Keep out of reach of children.
Do not exceed recommended dose.
If you have a bad reaction to this product, discontinue use.
When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Warning: These products are not intended to diagnose, treat, cure or prevent any disease. Please consult with a healthcare professional before starting any diet or exercise program. Some of these products are not recommended for individuals under the age of 18.

This page was last modified on Wednesday July 30, 2008