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LE698
Natural Relief 1222, 2 oz. tube
$21.00
Natural Relief is a powerful, safe and effective topical analgesic
that has been shown to be beneficial against the pain associated with
inflammatory conditions.* NFL professional football trainers and athletes have
praised Natural Relief as the most effective ointment to combat pain, stiffness,
and injuries. The USA Track and Field and Olympic Association Committee (OAC)
has tested and approved Natural Relief for use by its elite athletes and U.S.
Olympic team who went to Athens in 2004.
Supplement Facts
Active ingredients: Bryonia 6X (Bryonia alba), Rhus toxicodendron 6X.
Inactive ingredients: shark liver oil, garlic oil, almond oil, soybean oil.
Caution
If condition worsens or symptoms persist for more than seven days, discontinue
use of product and consult a physician. Do not use this product if you are
hypersensitive to any of the ingredients. Keep this and all drugs out of reach
of children. For external use only. Avoid contact with eyes.
Warnings
-
Keep out of reach of children.
-
Do not exceed recommended dose.
-
If you have a bad reaction to this product,
discontinue use.
-
When using nutritional supplements, please inform
your physician if you are undergoing treatment for a medical condition or if
you are pregnant or lactating.
Natural Analgesic Cream Relieves Everyday Aches and Pain
By Dave Tuttle
Persistence Leads to Invention
Like many older people, H. Edward Troy, PhD, suffered from arthritis. As head
research pharmacologist for a major international pharmaceutical company, Dr.
Troy was familiar with investigations of new and innovative drugs, and well
aware of the limited options available to arthritis sufferers. Like most
sufferers, he had tried counter-irritant creams and capsaicin-based products, as
well as nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and
ibuprofen. Finally, he resorted to more powerful steroidal drugs such as
prednisone.
All of these products either did not work or had unacceptable side effects.
Eventually, he chose to dedicate his life to the research and development of an
analgesic that would offer significant pain relief while sparing sufferers the
dangerous side effects associated with many medications. By training and
experience, Dr. Troy knew that doctors and medical practitioners had long used
certain emollients that when applied topically provide remedial effects for the
pain and discomfort of arthritis. He theorized that these compounds could be
isolated and combined in a compatible, balanced, all-natural formula free of the
undesirable side effects of prescription drugs.
Despite his extensive knowledge in the field, Dr. Troy found it difficult to
find the ideal combination of ingredients. Some nutrients lacked sufficient
effectiveness, while others irritated the skin or had an unacceptable odor.
Nevertheless, Dr. Troy was not deterred. Motivated by his personal loss, he
continued to explore ever more esoteric nutrient blends, eventually achieving
success with a combination of over 18 different natural compounds. Remarkably,
Dr. Troy persevered in his quest for 14 long years, despite an extraordinary
1,221 failed attempts. His revolutionary new product was thus named Natural
Relief 1222.
Unique Blend of Nutrients
Natural Relief 1222 is an all-natural analgesic cream that contains no
traditional counter-irritants or capsaicin. Its proprietary combination of
botanical and organic ingredients has been shown to provide effective relief
without the icy-hot sensations and pungent locker-room odors commonly associated
with over-the-counter creams. Nor does it cause the gastrointestinal side
effects associated with aspirin and other NSAIDs.
This patented blend of nutrients is the only pharmaceutically prepared analgesic
compound that has been clinically shown to provide rapid, safe, and effective
pain relief without side effects in both shallow and deep body tissues. Suitable
for use by sufferers of arthritis, neuritis, bursitis, and various skin trauma
conditions, Natural Relief 1222 contains a unique mixture of natural compounds
developed in an innovative chemical engineering process that combines them in a
balanced, compatible formula. While the formulation is considered proprietary
information, Dr. Troy has revealed that it includes shark liver oil and
deodorized garlic oil, both of which have clearly demonstrated anti-inflammatory
benefits. The effectiveness of these oils is enhanced when they are bonded
together and combined with the other nutrients in this patented blend. The
formulation also contains vitamin E.
Natural Relief 1222 has several mechanisms of action. The first is its
ability to neutralize free radicals. As Life Extension members know, free
radicals are unstable molecules with a great affinity for oxygen. This makes
them very dangerous because they can damage everything from the walls of blood
vessels to the membranes and cartilage tissues around joints.1
Antioxidants block the addition of oxygen to free radicals. Garlic oil contains
selenium and zinc, two minerals with significant antioxidant properties. The
vitamin E in the formulation also contributes to this neutralization process.
Natural Relief 1222’s second major mechanism of action is the interruption
of an important inflammatory pathway in the body. Omega-6 fat metabolism
follows the arachidonic acid cascade, whose end products are various
inflammatory prostaglandins, thromboxanes, and leukotrienes.2,3
Cortisone, the NSAIDs, and some newer products try to interrupt the formation of
these end products going down the chain, but they often have side effects that
are problematic at best.4 Omega-3 oils, such as shark liver oil, can
modulate arachidonic acid metabolism, reducing arachidonic acid concentrations
and increasing EPA levels.5 This results in the production of
vasodilating prostaglandins, leuko-trienes, and thromboxanes that do not produce
inflammation or that block the ones that do through the regular cyclooxygenase
and 5-lipoxygenase cascades. This also prevents the onrush of blood cells and
causes those already present to lose their stickiness.6
Natural Relief 1222 also contains two botanically based extracts, Bryonia
alba 6x and Rhus toxicodendron 6x. Bryonia alba 6x has been traditionally used
in the treatment of aching muscles, stitching pains, pressure and sinus
headaches, and painful stiffness in the nape of the neck and the lower back.7
Bryonia alba 6x is also indicated for rheumatic pains, joints that are red,
swollen, and stiff, and pain in the knees.7 Rhus toxicodendron 6x has
been classically used in the treatment of pain in the joints and tendons,
sprains and strains, tearing pains, sciatica, tenderness of the knee joints, low
back pain, and stiffness of the neck.8 Rhus toxicodendron 6x has also
been used in the management of stiff arms and legs, pain in the jaw, and facial
neuralgia.8 These botanically based ingredients make Natural Relief
1222 suitable for a wide range of therapeutic applications.
Clinical Trials Demonstrate Effectiveness
Three clinical trials have been conducted on Natural Relief 1222. The first
was performed by the California Research Foundation, a private organization in
San Diego, CA, that has investigated drugs and supplements for more than 60
pharmaceutical companies.9 Forty-eight patients with rheumatoid
arthritis and/or osteoarthritis participated in this two-week study. After the
volunteers were divided into two groups of equal age, duration of arthritis, and
baseline condition, half received Natural Relief 1222 and the other half were
given a placebo cream. At the initial baseline visit, the patients were screened
to determine whether they met the inclusion and exclusion criteria. Medical
histories were obtained and physical exams performed, including an evaluation of
the patient’s arthritic symptoms using a visual analog scale. During this visit,
the respective cream was applied and the patients remained in the clinic for 30
minutes to rate their pain. The volunteers were then instructed to apply the
product to their arthritic areas four times per day: on awakening and at lunch,
dinner, and bedtime for 14 consecutive days. At a second visit seven days later,
the investigator and test subject assessed the changes, if any, in arthritic
symptoms. Volunteers were also questioned about product compliance, concomitant
medication use, and adverse effects. This procedure was repeated again at the
end of the study period.
Statistical comparisons of the two groups revealed that those using Natural
Relief 1222 had a significantly higher improvement score, beginning 30 minutes
after the first treatment. Of the 24 patients receiving the formulation, 13
(54.2%) showed improvement in their limitation of motion, compared to 3 of 24
(12.5%) in the placebo group. The overall visual analog pain scores showed that
the difference between the two groups from baseline to the final visit was
greatest in those who had the highest baseline levels. The researchers also
noted that there was an absence of systemic side effects during the study.
Paul A. Repicky, PhD, performed the second study, to rate the relative
effectiveness of Natural Relief 1222 as a treatment for arthritis pain, joint
pain, and muscle stiffness.10 Seventy-two subjects were selected from
a group of patients who were using another product for symptom relief at the
start of the study period. The subjects were asked to rate the effectiveness of
the analgesic or anti-inflammatory medication they were using on a scale of 1
(least effective) to 4 (most effective). They were then asked to stop the use of
their medications before application of Natural Relief 1222. The volunteers were
told to apply the cream to the affected area once daily for three days. After
three days, they were asked to rate it using the same scale for effectiveness
they had used for their other medication.
The results showed the clear superiority of Natural Relief 1222. More than
80% of the study participants ranked this cream as more effective: 83% said it
was the most effective treatment for their pain, while 82% found it most
effective for increasing their range of motion. In addition, 85% of the patients
with arthritis ranked it as best for pain and 80% of the subjects with soft
tissue injuries gave it top marks for pain relief. The speed of action was
impressive, with many patients reporting an alleviation of symptoms after the
initial application. None of the subjects reported any side effects or allergic
reactions using Natural Relief 1222.
These two studies provide convincing evidence that Natural Relief 1222 is
superior to other creams on the market. The Life Extension Foundation conducted
its own study to conclusively determine the desirability of Natural Relief 1222.
The 16 study participants evaluated the previous products that they had used for
symptom relief and noted the improvements experienced with this new cream. For a
number of them, Natural Relief 1222 was the first product they had tried that
offered substantial relief from symptoms. The participants also rated this cream
more natural and easier and more pleasant to use than creams or gels that they
had used previously. In all, 87.5% found the cream superior to what they used
previously, and 93.8% said that they would recommend the product to friends and
family.
A New Way to Relieve Pain
Millions of people suffer from the debilitating pain of rheumatoid arthritis and
osteoarthritis. Even more put up with occasional muscle strains and soreness due
to unexpected, overly strenuous exertion in their daily lives. While products
such as ArthroPro help to rebuild joint cartilage and reduce inflammation
through multiple mechanisms, additional relief is sometimes needed. This is when
Natural Relief 1222 can be of benefit. Its unique combination of natural oils
and organic ingredients is able to produce immediate relief from the pains many
of us experience in our daily lives. It has been shown to be strong enough to
meet the requirements of Olympic athletes and professional football players, as
well as of older adults with a wide range of symptoms.
Supplement Facts
Active ingredients: Bryonia 6X (Bryonia alba),
Rhus toxicodendron 6X.
Inactive ingredients: olive squalane, garlic oil, almond oil, soybean oil.
Natural Relief
1222™ and Natural Relief 1222™ logo are trademarks of NR1222 LLC. All rights
reserved.
Product References
Inflammatory Reactions
1. Eur J Clin Invest. 2004 May;34(5):335-41.
2. JAMA. 2004 Feb 11;291(6):704-10.
3. Ann Rheum Dis. 2004 Feb;63(2):200-5.
4. Biol Psychiatry. 2003 Sep 1;54(5):566-72.
5. Immunol Allergy Clin North Am. 2003 Feb;23(1):15-39.
6. Am J Clin Nutr. 2000 Jan;71(1 Suppl):176S-8S.
7. Arthritis Rheum. 1996 Nov;39(11):1808-17.
8. J Chromatogr. 1992 Feb 21;592(1-2):271-8.
9. Arzneimittelforschung. 1998 May:48(5)469-74.
10. J Exp Zool. 1995 Sep;273(1):82-6.
11. J Rheumatol. 2000 Jan;27(1):20-5.
12. Mutat Res. 2004 Jul;551(1-2):245-54.
13. Mol Pharmacol. 1995 Jun;47(6):1212-6.
14. Arzneimittelforschung. 1996 Apr;46(4):389-94. Erratum in:
Arzneimittelforschung 1996 Sep;46(9):936.
15. FEBS Lett. 1999;442(1):89-94.
16. J Korean Med Sci. 1999 Jun;14(3):231-8.
17. Dennis and Company Research. Nexrutine© human trial report. Next
Pharmaceuticals, Inc. 2002;13.
18. Mol Pharmacol. 1995 Jun;47(6):1212-6.
19. Chem Pharm Bull (Tokyo). 1992; 40(2): 387-391.
20. Med Hypotheses. 1989; 29(1): 25-8.
21. Prostaglandins Leukot Med. 1986 Oct;24(2-3):195-8.
22. Arzneimittelforschung. 1998 May;48(5):469-74.
23. Arch Intern Med. 2003 Jul 14;163(13):1514-22. Comment in:
Arch Intern Med. 2004 Feb 9;164(3):338-9; author reply 339.
J Fam Pract. 2003 Dec;52(12):919-20.
24. Curr Med Res Opin. 1980;7(2):104-9.
25. BiochemBiophys Acta. 2004 Jun 1;1682(1-3):80-91.
26. Am J Clin Nutr. 2000 Sep;72(3):804-8.
27. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91
28. Biofactors. 2000;11(1-2):11-3.
29. Harv Health Lett. 2003 Aug;28(10):6.
30. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar,58(3):185-91.
31. J Nutri Sci Vitaminol. 2003 Dec;49(6):442-6.
32. Integr Cancer Ther. 2002 Mar;1(1):7-37; discussion 37.
33. Proc Natl Acad Sci USA. 2003 Feb 18;100(4):1751-6.
34. J Exp Med. 2002 Oct 21;196(8):1025-37.
35. J Biol Chem. 2000 Jan 14;275(2):721-4.
36. Clin Nutr. 2004 Apr;23(2):139-51.
37. Ann Nutr Metab. 2004;48(1):28-35. Epub 2003 Nov 20.
38. Biomed Pharmacother. 2002 Oct;56(8):365-79.
39. Am J Clin Nutr. 2003 Sep;78(3 Suppl):640S-646S.
40. Br J Nutr. 2003 Aug;90(2):311-21.
41. Phytochemistry. 2003 May;63(2):139-43.
42. Med Hypotheses. 1981 Sep;7(9):1211-20.
43. Eksp Klin Farmakol. 2002 Nov-Dec;65(6):67-9 (in Russian).
44. Fortschr Med. 1980 Jun 5;98(21):801-6 (in German).
45. Menopause. 2004 Mar-Apr;11(2):138-43. Comment in:
Menopause. 2004 Mar-Apr;11(2):134-5.
46. http://www.arthritis-glucosamine.net/glucosamine/science/glucosamine-sulfate.html
47. Pharmacology. 1971;5(6):337-45.
48. Pharmacol Res Comm. 1978; 10: 557-569
49. Altern Med Rev. 2003 Nov;8(4):438-41. http://www.thorne.com/altmedrev/.fulltext/8/4/438.pdf
50. J Agric Food Chem. 1981 Sep-Oct;29(5):1089-91.
51. J Altern Complement Med. 2002 Apr;8(2):167-73.
52. Biomaterials. 2001 Sep;22(17):2359-69.
53. Osteoarthritis Cartilage. 1998 May;6 Suppl A:39-46.
54. Osteoarthritis Cartilage. 1998 May;6 Suppl A:37-8.
55. Arthritis Rheum. 1988 Jan;31(1):63-71.
56. Osteoarthritis Cartilage. 2001 Jan;9(1):14-21.
57. Arzneimittelforschung. 1998 May;48(5):469-74.
58. Osteoarthritis Cartilage. 2003 Apr;11(4):290-8.
59. J Immunol. 2001 Apr 15;166(8):5155-60.
60. Arthritis Rheum. 1990 Apr;33(4):477-84.
61. Adv Immunol. 1997;64:283-350.
62. Life Sci. 2004 Jan 23;74(10):1289-305.
63. Arthritis Res Ther. 2003;5(3):R122-31. Epub 2003 Mar 06.
64. Free Radic Res. 2003 Mar;37(3):257-68
65. Biochimie. 1999 Oct;81(10):955-63.
66. Wien Med Wochenschr. 2002;152(15-16):373-8 (in German).
67. Planta Med. 2001 Jul;67(5):391-5.
68. Planta Med. 2000 Mar;66(2):110-3.
69. Eur J Med Res. 1998 Nov 17;3(11):511-4.
70. Eur J Med Res. 1997 Jan;2(1):37-43.
71. J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
72. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
73. Planta Med. 1991 Jun;57(3):203-7.
74. Menopause. 2004 Mar-Apr;11(2):138-43.
75. Br J Sports Med. 2003 Feb;37(1):45-9; discussion 49.
76. Ann Pharmacother. 1998 May;32(5):574-9.
77. Arzneimittelforschung. 1994 Jan;44(1):75-80.
78. Curr Med Res Opin. 1980;7(2):110-14.
79. Curr Med Res Opin. 1980;7(2):104-9.
80. Pharmacol Res Commun. 1978 Jun;10(6):557-69.
81. Osteoarthritis Cartilage. 1998 May;6 Suppl A:37-8.
82. Arthritis Rheum. 1988 Jan;31(1):63-71.
83. Osteoarthritis Cartilage. 2001 Jan;9(1):14-21.
84. Arzneimittelforschung. 1998 May;48(5):469-74.
85. Arthritis Rheum. 1995 Aug;38(8):1107-14.
86. Eur J Clin Invest. 1992 Oct;22(10):687-91.
87. Scand J Rheumatol. 1992;21(4):178-85.
88. Ann Rheum Dis. 1990 Feb;49(2):76-80.
89. J Rheumatol. 1988 Oct;15(10):1471-5.
90. Ann Rheum Dis. 1988 Feb;47(2):96-104.
91. Ann Intern Med. 1987 Apr;106(4):497-503.
92. Mil Med. 1999 Feb;164(2):85-91.
93. Arthritis Rheum. 1996 Nov;39(11):1808-17.
94. Br J Rheumatol. 1994 Sep;33(9):847-52.
95. Nutr Rev. 2004 Jan;62(1):18-27.
96. Fortschr Med. 1989 Feb 10;107(4):67-8, 71-2 (in German).
Printed with permission of Life Extension
www.lef.org.
Article References
1. Davies KJ. Oxidative stress: the paradox of aerobic life.
Biochem Soc Symp. 1995;61:1-31.
2. Simopoulos AP. The importance of the ratio of
omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002
Oct;56(8):365-79.
3. Simopoulos AP. Omega-3 essential fatty acids in
inflammation and autoimmune diseases. J Am Col Nutr. 2002 Dec;21(6):495-505.
4. Brune K. Safety of anti-inflammatory treatment—new ways of
thinking. Rheumatology. 2004 Feb;43(Suppl 1):16-20.
5. Garg ML, Thomson AB, Clandinin MT. Interactions of
saturated, n-6 and n-3 polyunsaturated fatty acids to modulate arachidonic acid
metabolism. J Lipid Res. 1990 Feb;31(2):271-77.
6. Dannhardt G, Kiefer W. Cyclooxygenase inhibitors: Current
status and future prospects. Eur J Med Chem. 2001 Feb;36(2):109-26.
7. Available at: http://data.widgetworks.com:591/boericke/FMPro?-db=boericke.fp5&-format=record%5fdetail.htm&-lay=browse%20copy&-sortfield=name&-op=cn&Search=bryonia&-max=20&-recid=32823&-find.
Accessed August 26, 2004.
8. Available at: http://data.widgetworks.com:591/boericke/FMPro?-db=boericke.fp5&-format=record%5fdetail.htm&-lay=browse%20copy&-sortfield=name&-op=cn&Search=tox&-max=20&-recid=33527&-find.
Accessed August 26, 2004.
9. Brandon ML. A double-blind placebo-controlled study
evaluating the effectiveness of topically applied Natural Relief 1222 in
relieving pain and stiffness in subjects with rheumatoid and/or osteoarthritis.
June 15, 1998; San Diego, CA.
10. Repicky, P. An all-natural topical analgesic cream for the
treatment of pain and stiffness. April 1, 1995; San Diego, Calif.
Warning: These products are not intended to diagnose, treat, cure or prevent
any disease. Please consult with a healthcare professional before starting any
diet or exercise program. Some of these products are not recommended for
individuals under the age of 18.
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