Kyolic Reserve Garlic 600 mg. 120 caps.

The market is flooded with numerous garlic products, with each manufacturer claiming their products provide maximum health benefits. One must be careful, however, in choosing a garlic supplement.

When garlic is aged, its harsh and highly odorous compounds are converted into more beneficial and much less odorous compounds. Numerous studies have suggested that supplementing one’s diet with aged garlic extract may be beneficial. Published data about aged garlic extract shows that it:

Helps maintain healthy endothelial function and structure^1,2Helps maintain healthy immune function^3,4
Helps maintain healthy cellular DNA structure^5,6

There are more published studies substantiating the multiple benefits of Kyolic^® Aged Garlic Extract^TM than any other brand. While some other garlic preparations may work as well as Kyolic^®, the sheer volume of studies highlighting Kyolic’s benefits makes it the garlic supplement of choice.

Supplement Facts

Serving Size 1 capsule
Servings Per Container 120
Amount Per Serving
Aged Garlic Extract™ (Special Garlic Preparation) Powder (bulb)	600 mg
Other ingredients: gelatin, cellulose, magnesium stearate (vegetable source) and silica.

Free of preservatives, sugar, sodium, milk, yeast, gluten, artificial colors and flavors.

Dosage and Use
Take one or more capsule(s) as needed with a meal twice daily.

References

1. Planta Med. 1989 Dec;55(6):506-8.
2. Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:138P-141P
3. Cancer Immunol Immunother. 1993 Oct;37(5):316-22.
4. Mol Biother. 1991 Jun;3(2):103-7.
5. Carcinogenesis. 1993 Aug;14(8):1627-31.
6. Carcinogenesis. 1992 Oct;13(10):1847-51.

More information on the Benefits of Garlic

Garlic has been shown to support a healthy immune system. Studies have demonstrated its effectiveness against:

* Hypertension
* Cancer
* Inflammation
* Virus replication and proliferation
* Free radical damage
* Vascular calcification/atherosclerosis

Herbalists routinely claim that garlic (Allium sativum) is the world’s longest-used medicinal food. The therapeutic use of garlic predates written history by several millennia, with the earliest mention dating back more than 5,000 years ago to Sanskrit records in India.¹ Garlic was already a long-favored remedy in ancient medicine 1,000 years before the birth of Christ. Ancient Egyptians worshipped the spice as a god, valuing it so much that 15 pounds of garlic would purchase a healthy male slave.

Twentieth-century science relegated garlic to a state of relative neglect medicinally, if not in the kitchen. In recent years, however, garlic has moved to the forefront of an explosion of interest in natural remedies. According to the UCLA Center for Human Nutrition in Los Angeles, diets rich in plant foods are associated with a reduced risk of heart disease and cancer. These plant foods contain phytochemicals that have anti-cancer and anti-inflammatory properties. Garlic and other white-green foods in the onion family contain allyl sulphides, which may inhibit the growth of cancer cells.²

Today, garlic is the subject of considerable research for its medicinal properties, and new clinical trials are yielding proof of its role as a powerful antioxidant. Garlic also shows promise in protecting against heart disease, hypertension, and cancer.

Scavenging Free Radicals

Implicated in many serious illnesses, free radicals are harmful byproducts of cellular metabolism. Antioxidants scavenge free radicals.

Sulfur-containing compounds, found in all body cells, are indispensable to living organisms. Unlike humans, plants can use inorganic sulfur to synthesize sulfur-containing amino acids. Many strong antioxidant compounds are rich in sulfur, including N-acetylcysteine, taurine, lipoic acid, and glutathione. Plants are an important source of sulfur for humans, and garlic is a major source of organosulfur compounds.³

Two separate studies focused on S-allylcysteine, a garlic-derived compound and well-characterized scavenger of free radicals. S-allylcysteine scavenges free radicals and reduces oxidative stress.^6,7 In experimental animal models, S-allylcysteine helped protect the nervous system from neurotoxins and the kidneys against damage from reactive oxygen species.^6,7

Protecting the Heart

In recent years, atherosclerosis has emerged as one of the leading causes of death in nations whose diets are disproportionately high in saturated fats and cholesterol. A Czech study investigated garlic’s inhibitory effect on the biosynthesis of cholesterol and fatty acids. Positive results manifested in reduced arterial plaque and markedly decreased accumulation of cholesterol in the vascular walls.⁸

Aged garlic extract has been shown to reduce multiple cardiovascular risk factors, including blood pressure, cholesterol, and platelet aggregation and adhesion, while stimulating the generation of nitric oxide in endothelial cells.¹²A recent, double-blind, placebo-controlled study evaluated aged garlic extract’s ability to inhibit vascular calcification, a marker of plaque formation in human coronary arteries, in 23 patients with atherosclerosis.¹²The results suggested that aged garlic extract may inhibit the progression of coronary calcification, suggesting a therapeutic role for garlic in patients at high risk for future cardiovascular events.¹²

Taking the Pressure Off
Hypertension, or high blood pressure, is a silent but potentially deadly disease. Research suggests that garlic supplementation may provide important benefits for hypertensive patients.

Researchers at the University of Mississippi investigated hypertension treatment using natural, commonly available dietary supplements and stress-reducing lifestyle modifications.¹³ Garlic showed the potential to reduce systolic blood pressure by at least 9 mmHg and diastolic blood pressure by at least 5 mmHg.¹³

A subsequent Turkish clinical trial took this evidence further, finding that garlic extract supplementation over four months markedly lowered systolic and diastolic blood pressure values in hypertensive volunteer subjects with high blood cholesterol.¹⁴ In those with normal blood pressure, garlic did not affect blood pressure levels.¹⁴

Ally in the Cancer War
For thousands of years, traditional medical practitioners have used garlic and other members of the Allium genus to treat cardiovascular disease.¹⁵ Garlic’s use as a remedy for tumors extends back to the Codex Ebers of 1550 BC, an Egyptian medical papyrus.¹⁶ Recent extensive research has focused on the anticarcinogenic potential of allium vegetables and their constituents, allylsulfides (organosulfur compounds) and flavonoids.

Modern epidemiological studies, well correlated with laboratory investigations, corroborate the evidence that higher intake of allium products is associated with reduced risk of several cancers.¹⁵The mechanisms proposed to explain the cancer-preventive effects of garlic include inhibition of tumor mutagenesis, modulation of enzyme activities, and effects on cell proliferation and tumor growth.¹⁵

The antioxidant effects that prevent DNA damage and cancer-causing mutations are essential to the cancer preventive effects of garlic and its components. In addition, aged garlic extract, and lipid soluble organosulfur compounds that are also found in garlic powder, prevent the binding of DNA and chemical carcinogens. They also increase the disposal of the carcinogens in animals, ridding the body of the cancer causing agents.

Other animal studies show that aged garlic extract protects against early and late stages of cancer development in the colon, mammary glands, skin, stomach and esophagus. Among the compounds in the garlic extract showing prevention of tumor promotion is allixin, a flavonoid that also prevents the formation of prostaglandins, hormone-like substances that are active in enhancing inflammation, platelet aggregation and tumor growth.

Several garlic compounds, including allicin, induce apoptosis (programmed cell death) in various malignant human cells. These include breast, colorectal, hepatic, prostate, and lymphoma cells.¹⁶A growing number of clinical studies are examining the properties of ajoene, the major sulfur-containing compound purified from garlic. Ajoene has the advantage of being more chemically stable than allicin, and researchers are investigating its possible role in the prevention and treatment of cancer.^17,18

Garlic has demonstrated few toxic side effects. While eating garlic cloves is a proven way to obtain the benefits of their organosulfides, unwelcome side effects include bad breath and perspiration. Fortunately, garlic supplements provide all the benefits of eating raw garlic without these undesirable effects.

Enhanced immune functions

The immune system consists of many types of cells and protective substances that fight infections, the common cold and help battle life threatening diseases, such as cancer. A strong immune system can defend against bacteria, viruses and fungal diseases. When immunity is severely damaged, as in the case of AIDS, the body cannot fight off invading infectious organisms. Immunity can be compromised by many factors, by a poor diet, stress, environmental pollution, disease and aging. Fortunately, science has identified dietary substances that help stimulate the immune system, and garlic is among them.

Human studies confirm immune stimulation by garlic. Subjects receiving aged garlic extract at 1800 mg a day for three weeks showed a 155.5% increase in natural killer immune cell activity that kills invaders and cancer cells. Other subjects receiving large amounts of fresh garlic of 35g a day, equivalent to 10 cloves, showed an increase of 139.9%. In six weeks, patients with AIDS receiving aged garlic extract showed an enhancement of natural killer cells from a seriously low level to a normal level.

In another human study, subjects were given garlic powder for three months. Blood samples tested for white cell activity, showed an increased capacity of the immune cells to engulf the E. coli bacteria. Garlic and garlic preparations increase the activity of immune cells, including macrophages, that kill infectious invaders.

Recent studies show that garlic powdered extract contains substances that kill Heliobacter pylori, a virulent organism that grows in the stomach and is thought to be associated with stomach ulcers and stomach cancer. Since 122 patients out of 145 people infected with H. pylori showed resistance to antibiotic treatment, treatment with garlic supplementation may be an essential approach.

Warnings

Keep out of reach of children.
Do not exceed recommended dose.
If you have a bad reaction to this product, discontinue use.
When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Warning: These products are not intended to diagnose, treat, cure or prevent any disease. Please consult with a healthcare professional before starting any diet or exercise program. Some of these products are not recommended for individuals under the age of 18.

Excerpt from: Laifer, Stephen. "Garlic: Medical Science Discovers New Uses for an Ancient Herb", LE Magazine, April 2005

References
1. Riddle JM. Garlic’s history as a medicine. Paper presented at: American Herbal Products Association International Garlic Symposium; July 31, 2001.

2. Heber D. Vegetables, fruits and phyto-estrogens in the prevention of diseases. J Postgrad Med. 2004 Apr;50(2):145-9.

3. Atmaca G. Antioxidant effects of sulfur-containing amino acids. Yonsei Med J. 2004 Oct 31;45(5):776-88.

4. Perez-Severiano F, Rodriguez-Perez M, Pedraza-Chaverri J, et al. S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats. Neurochem Int. 2004 Dec;45(8):1175-83.

5. Maldonado PD, Barrera D, Rivero I, et al. Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. Free Radic Biol Med. 2003 Aug 1;35(3):317-24.

6. Sovova M, Sova P. Pharmaceutical importance of Allium sativum L. 5. Hypolipemic effects in vitro and in vivo. Ceska Slov Farm. 2004 May;53(3):117-23.

7. Durak I, Kavutcu M, Aytac B, et al. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem. 2004 Jun;15(6):373-7.

8. Sengupta A, Ghosh S, Bhattacharjee S. Allium vegetables in cancer prevention: an overview. Asian Pac J Cancer Prev. 2004 Jul;5(3):237-45.

9. Hassan HT. Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy. Leuk Res. 2004 Jul;28(7):667-71.

10. Ledezma E, Apitz-Castro R, Cardier J. Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the alpha(4)beta(1) integrin. Cancer Lett. 2004 Mar 31;206(1):35-41.

11. Tilli CM, Stavast-Kooy AJ, Vuerstaek JD, et al. The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis. Arch Dermatol Res. 2003 Jul;295(3):117-23.

12. Xu B, Monsarrat B, Gairin JE, Girbal-Neuhauser E. Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells. Fundam Clin Pharmacol. 2004 Apr;18(2):171-80.

13. Lu HF, Sue CC, Yu CS, et al. Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells. Food Chem Toxicol. 2004 Oct;42(10):1543-52.

This page was last modified on Saturday December 08, 2007