SAMe (S-Adenosyl-methionine) 200 mg.,20 tablets

SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. It is widely used in Europe as an antidepressant. SAMe is used by the body in three important pathways: methylation (contributing methyl groups to activate certain molecules); the synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.); and trans-sulfuration (synthesis of cysteine, glutathione and other sulfate chemicals). In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the cofactors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency.

There is evidence that SAMe may:

be the fastest acting, safest and most effective antidepressant available.

help prevent and reverse liver disease.

be effective in the treatment of fibromyalgia, chronic fatigue syndrome and osteoarthritis.

help to synthesize phosphatidylcholine, which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine.

1 tablet contains:

200 mg of S-adenosyl-methionine in its diphosphate form.

Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch

glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow ochre.

Dosage and use

For people with depression, 1200-1600 mg per day are recommended. Take in divided dosages morning, midday, and late afternoon.

This product is most effectively utilized when taken on an empty stomach with water. Take with food if GI disturbance occurs.

Refrigeration is recommended.

Take folic acid, B12 and B6 when using SAMe.

Caution:

Do not use SAMe with other antidepressants except under a doctor’s care.

At levels above 400 mg daily, SAMe may cause dry mouth, restlessness and gastrointestinal problems. Cutting back on dosage and then increasing it slowly should alleviate these symptoms.

Warning: These products are not intended to diagnose, treat, cure or prevent any disease. Please consult with a healthcare professional before starting any diet or exercise program. Some of these products are not recommended for individuals under the age of 18.

This page was last modified on Thursday December 13, 2007