Newsletter Archive

Mega Green Tea Extract 100 caps.

The botanical extract in Mega Green Tea Extract has been concentrated and dual standardized to ensure the highest quality, consistency and biological activity. This advanced extract contains 98% total polyphenols (710.5 mg per capsule) and 45% Epigallocatechin gallate (EGCG) (326.25 mg per capsule). The antioxidant activity of EGCG is about 25- 100 times more potent than vitamins C and E. One cup of green tea may provide 10-40 mg of polyphenols and has antioxidant effects that are greater than a serving of broccoli, spinach, carrots, or strawberries.

The concentrated green tea extract plus naturally occurring caffeine in Life Extension's Mega Green Tea Extract can be a beneficial addition to your weight loss program.

LE953 Mega Green Tea Extract 98% Polyphenols 100 veg. caps. $17.85

Click here to learn more

Calcium Citrate with Vitamin D3 1000 mg. 300 caps.

Calcium is more effective when taken in smaller doses spread throughout the day and before bedtime. When taken at night, it also promotes a sound sleep. The citrate salt of calcium has been documented to be well absorbed and utilized by the body. Vitamin D is necessary for both the efficient absorption of dietary calcium and phosphate, as well as their metabolism once ingested.

Female athletes and women experiencing menopause need greater amounts of calcium due to lower estrogen levels. Estrogen protects the skeletal system by promoting the deposit of calcium in bone.

LE1015 Calcium Citrate with Vitamin D3 1000 mg 300 caps. $15.30

Feel Good Chocolate Diet 75 softgels

Irwin Naturals' Feel Good Chocolate Diet is a great help to a person who is following a diet and exercise routine in order to become leaner. This product contains ingredients that work together to keep you focused and upbeat while you are making efforts to burn off those unwanted pounds. This formula contains theobromine, green tea extract, theanine, rhodiola root extract, 5-hydroxytryptophan, CLA, yerba mate extract, ginger root extract, piper longum extract, black pepper extract, L-theanine, citrus bioflavonoids, magnesium, zinc and vitamin B6 .

IN111 Feel Good Chocolate Diet 75 softgels $14.97

Stevita Delight Cocoa Flavored Stevia 4.2 oz.

Stevita Delight Cocoa Flavored Stevia is a great pick- me-up and guilt-free treat. Perfect for baking, flavoring protein drinks, or making hot or cold chocolate drinks. It makes GREAT hot chocolate! It's only sweetener is organic stevia, a natural plant extract that has no effect on one's blood sugar level and is safe for diabetics. An incredible blend of Organic Stevia, cocoa and vanilla. (Silicon dioxide is added as an anti-caking agent). Simply dissolve 2 tsp. in a cup of hot or cold liquid and enjoy this wonderful dietary supplement with no sugar, artificial sweeteners and only 1.5g of effective carbohydrates per serving. 36 servings per container.

STV1036 Stevita Delight Cocoa Flavored Stevia 4.2 oz. 36 servings $4.63

Daily Complete Formula 180 tablets

Ultimate Nutrition's Daily Complete Formula provides a complete balance of vitamins essential to the normal functioning of our bodies. Minerals and trace minerals are added in their most bioavailable form to provide a superior product for the moderately active individual. One month supply.
For more active individuals Ultimate Nutrition has developed Super Complete Formula 270 tabs (one month supply). This formula has a higher dose of vitamins, minerals and antioxidants to compensate the body in need of higher nutritional requirements.

UN501 Daily Complete Formula 180 tablets $9.00
UN504 Super Complete Formula 270 tabs.$15.34

C Plus Citrus Bioflavonoids 250 caps. Sale Price $23.27

References

1.Pasman WJ, Saris WH, Wauters MA, et al. Effect of one week of fibre supplementation on hunger and satiety ratings and energy intake. Appetite. 1997 Aug;29(1):77-87.

2.Dulloo AG et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999;70(6):1040-5.

3.Berube-Parent S, et al. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24h energy expenditure and fat oxidation in men. Br J Nutr 2005;94(3):432-6.

4. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord. 2000 Feb;24(2):252-8.

5. Zheng G, Sayama K, Okubo T, Juneja LR, Oguni I. Anti-obesity effects of three major components of green tea, catechins and theanine, in mice. In Vivo. 2004 Jan-Feb;18(1):55-62.

6.Gilbert, M. Supplements for Weight Loss. Natural Foods Merchandiser Aug. 2006:42-4.

7.Ibid

8.Volpe SL, et al. Effect of chromium supplementation and exercise on body composition, resting metabolic rate and selected biochemical parameters in moderately obese women following an exercise program. J Am Coll Nutr 2001;20(4):293-306.

9.Campbell WW, et al. Effects of resistance training and chromium picolinate on body composition and skeletal muscle in older men. J Appl Physiol 1999;86 (1):29-39.

10.Zemel MB, et al. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 2004;12(4):582-90.

March 2009

Allergy Relief

March 2009

Relief from Allergies with Natural Support

With spring upon us the dreaded allergy season will soon be in full force. An allergy is an over reaction of the immune system induced by a particular allergen. It is a very common problem, affecting at least two of every 10 Americans. About 10 percent of children in the United States are allergic to one or more substances. Most allergies are inherited; when one parent is allergic, the child has a 50 percent chance of having allergies. That risk jumps to 75 percent if both parents have allergies.
An allergen is a substance that the body perceives as foreign and dangerous and causes allergic reaction. Common allergens include pollen (a fine, powdery substance released by plants and trees), animal dander, feathers, mites, chemicals, drugs, and a variety of foods. Pollens that cause allergic reactions come from plants: trees (oak, elm, birch, maple, hickory, cedar, juniper), grasses (timothy grass, Bermuda grass, orchid grass, velvet grass), and weeds (ragweed, desert broom, feverfew, and marigold family).
Allergy symptoms include respiratory problems, a stuffy and/or runny nose, sneezing, itchy skin, red and watery eyes, ache, fatigue, fever, diarrhea, stomachache, and vomiting. Symptoms could be seasonal or chronic depending on the allergen involved. Pollens from grass and trees usually cause seasonal allergies, while chronic allergies are usually caused by allergens present year-round, such as animal fur, dust, or feathers.
Asthma is an inflammatory disease that is characterized by narrowing of the bronchi (lung passageways) making air- flow into and out of the lungs restricted, and hence making breathing difficult and causing a feeling of not getting enough air into the lungs.
There are two types of asthma. One is triggered by an allergy (referred to as allergic asthma) and the other has no known cause. Asthma can be triggered by inhaled allergens, such as pet dander, dust, cockroach allergens, and mold spores. It can also be triggered by rapid changes in temperature or humidity, upper respiratory infections, exercise, stress, or smoke (cigarette).
Asthma is found in 3-5 percent of adults and 7-10 percent of children. Half of those with asthma develop it before age 10. Anyone can get asthma, although it tends to run in families. An estimated 12 million adults and children in the United States have asthma. There is no known way to prevent an episode of asthma, except keeping away from foods, irritating substances, or environmental allergens that might be suspected to trigger another episode. Symptoms include wheezing, shortness of breath, tightness in the chest, and frequent coughing.

Whenever possible, the best therapy for an allergic problem is to avoid the offending substance or substances. The environment of an allergic person should be kept as free of known allergens or potential allergens as possible. Allergy-proof and mite-proof covers should be used on all pillows, mattresses, and box springs in the sleeping area, and all bedding should be washed weekly in very hot (135°F) water. Mold exposure is to be avoided by eliminating moisture-laden growth areas and any new growth must be eliminated promptly. Mold-inhibiting substances are available and should be used freely on mold-prone surfaces. Pets should be kept out of the sleeping area. Cats and dogs should be bathed frequently to reduce the amount of surface allergens on their bodies. Air-conditioning is helpful for pollen allergies, but filters must be changed regularly.

For patients with respiratory allergies, which are not being adequately controlled, consideration should be given to possible rebound or irritant effects such as occurs with nasal sprays. Potent vasoconstrictors such as oxymetazoline (present in many nasal sprays) are well known for causing a rebound-type effect. Less frequently recognized is an effect caused by some of the preservatives commonly used in nasal sprays, both prescription and over-the-counter preparations. Benzalkonium chloride is still used as a preservative in most prescription and over-the-counter sprays for the treatment of allergy, and some such products still contain phenylmercuric acetate, an organic mercury product. If symptoms are not being properly controlled, allergy and/or irritation relative to one or more components in the medications should be suspected.

People with asthma or allergies should eat a healthy diet and avoid foods such as nuts, yeast-based foods, seafood, dairy foods, and foods containing preservatives or dyes. Certain food additives, especially meta-bisulfite, can be dangerous for the child with asthma. Monosodium glutamate can also cause problems for some people with asthma.

Nutritional Support

Rosmarinic acid extract is a new alternative to painful allergy shots and pills that provide only partial relief from allergic symptoms. Rosmarinic acid, a plant polyphenol derived from rosemary leaf, provides effective, temporary relief of allergy symptoms. Unlike antihistamines, rosmarinic acid both prevents the activation of immune responder cells and kills excess allergy-activated immune cells.

Magnesium has been used to treat acute asthma attacks. lntracellular magnesium levels are usually low among asthmatics. Intracellular magnesium was assessed in 22 asthma patients and compared with 38 controls. Magnesium levels were significantly lower in individuals with asthma versus controls.(1) Magnesium helps relax smooth muscles in the bronchial tubes. A therapeutic daily dose of 400 to 800 mg is recommended.

Coenzyme Q1O (CoQ10). In a recent study, CoQ1O concentrations in both plasma and whole blood of 56 men and women, ages 19 to 72, suffering from allergic asthma were found to be significantly lower compared to 25 healthy subjects ages 25 to 50. The study suggested that supplementation with COQ10 might help patients with asthma.(2).

Essential Fatty Acids. Adequate supplements of essential fatty acids with omega-6 and omega-3 types should be taken because these have an anti-inflammatory effect when taken together. A pro-inflammatory effect of common unhealthy dietary fats is the overproduction of arachidonic acid. This pro-inflammatory effect is blocked by the omega-3 fatty acids. The omega-3 essential fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are found in the oil from fatty fish. The minimum dose of EPA/DHA is 1400 mg daily. Precursors of EPA/DHA are found in flax and perilla seed oils. Minimum dose is 6000 mg daily. A potent anti-inflammatory fatty acid is GLA (gamma- linolenic acid), which can be obtained from evening primrose, black currant seed, or borage oils. A suggested dose would be 900-1500 mg daily of GLA from these oils. Borage oil provides the highest concentration, thereby requiring fewer capsules to be taken. All supplements, if possible, should be kept in the refrigerator or freezer and should be taken at the beginning of a meal to reduce heartburn and after- taste.

MSM (Methyl-sulfonyl-methane) is composed of sulfur, which helps alleviate allergies through detoxification and elimination of free radicals. In a recent study, 50 subjects with seasonal allergy symptoms were given 2,600 mg of MSM orally per day for 30 days. All respiratory symptoms were significantly improved by the third week. The study concluded that MSM might be efficacious in the reduction of symptoms associated with seasonal allergies.

Flavonoids, particularly rutin and quercetin, have anti-allergy effects (Fanning et al. 1983) and team up well with vitamin C, as do the oligomeric proanthocyanidins (OPC) found in grape seed extract. Proanthocyanidins (grapeseed extract) may be taken (100 mg) one to three times a day. Bucca et al. (1990) found that compared to a placebo, 2 grams of vitamin C improved pulmonary function 1 hour after taking. Featon et al. (2000) found a sevenfold increase in bronchial hyperreactivity among those with the lowest intake of vitamin C. Quercetin, a bioflavonoid, is anti-histaminic and anti-allergic. It was shown to inhibit mast cells from releasing inflammatory compounds.(3)

N-Acetyl-Cysteine. Glutathione (GSH) is a naturally occurring tripeptide that protects every cell from toxic free radicals. It contains the three amino acids glycine, glutamic acid, and cysteine. N-acetyl- cysteine (NAC) is an acetylated ester of the amino acid, cysteine. NAC has a powerful effect on raising glutathione levels in the body. In fact, it has been found more potent than giving glutathione itself. For many years, NAC has been used in the treatment of bronchitis and other lung conditions as an expectorant or mucous thinner as well as for its anti-inflammatory effects. NAC is also the treatment of choice to reduce the toxicity of acetaminophen, particularly when toxic doses are present. NAC has been shown to enhance T-cell function. NAC should be taken in a dose of 600 mg once daily. NAC should be accompanied by vitamin C, 1000 mg or more per 600 mg of NAC, to maintain its effectiveness.

Probiotics are thought to improve the balance of germs in the intestines, which may enhance the immune system. In a Finnish study published in the Lancet medical journal (2001), 159 pregnant women with a family history of allergies were randomly given either Lactobacillus GG or placebo twice a day for three weeks before they gave birth. After they delivered, breast-feeding mothers took the probiotic capsules for six months, while bottle-fed babies were fed the contents of the capsules mixed with water for the same amount of time. By age 2, 23 percent of those fed probiotics had developed eczema, compared with 46 percent of the infants given placebo treatments.

DHEA is a steroid hormone produced by the adrenal glands. It is used by the body in a variety of functions and acts as a precursor for male and female hormones. DHEA is the most abundant steroid in the bloodstream and is present in highest levels in brain tissue. DHEA can modulate autoimmune reactions and has been used in treating conditions such as lupus erythematosis. Levels of DHEA are found to be progressively lower in people as they age and supplementation has been shown to reverse some of the effects of aging on the immune system (Weksler 1993). DHEA is contraindicated in men and women with certain hormone related cancers.

Allergy shots, prescription drugs and over-the-counter medicines, nasal sprays and antihistamines all have potentially harmful side effects including suppressing the immune system. The natural alternatives discussed above may provide relief without the side effects and at the same time support the immune system.

Why not try the natural approach this allergy season as you may find that you will not longer need the prescription immune-suppressing allergy treatments that you have relied upon.

References

1. Dominguez LJ et al. Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effect of magnesium in asthma. Clin Sci (Coich) 1998; 95:137
2. Gazdik F et al. Decreased levels of COQ10 inpatients with bronchial asthma. Allergy 2002;57:811
3. Pearce FL et al. MucoW mast cells: effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol 1984; 73:819

allergy symptoms.
Allergies are characterized by the excess proliferation of immune responder cells in the bloodstream and nasal fluids.1 This enormous influx of responder cells to the airways and nasal passages produces the congestion, fluid outpouring and swelling that allergy sufferers find so debilitating. Unlike antihistamines, rosmarinic acid both prevents the activation of immune responder cells and kills excess allergy- activated immune cells.
Rosmarinic Acid 100 mg. 60 caps. Sale Price $24.23

Magnesium Citrate

As magnesium levels decline, the incidence of allergies and asthma increases. Asthma is largely due to allergies. Asthma can be brought on by many causes: food and beverages, and the sulfites in them, or environmental allergens: fresh paint, perfumes, spray deodorants, cigarette smoke, gasoline or car exhaust fumes; hay, wood, coal or chalk dust; various chemicals such as cleaning solvents, household cleaners and insecticides; pollen and mold. A dose of 1000 mg per day is recommended to avert allergies and asthma.
Magnesium Citrate 160 mg. 100 caps. Sale price $5.78

Vitamin C Plus Citrus Bioflavonoids

Herbs and plant products are extremely helpful for asthma. Michael Heinrich, at the Center for Pharmacognosy and Phytotherapy, School of Pharmacy, in London, discovered that a key target for asthma (as well as arthritis) is the nuclear factor kappa B (NF-kappaB) transduction pathway, which activates many inflammatory cytokines. Some well- known plant chemicals that target NF-kappaB include several phenolics such as curcumin (in curcumin), and flavonoids. The flavonoid quercetin helps reduce allergic reactions, asthma, and hay fever by preventing the release of histamine. By blocking the release of histamine rather than acting on histamine receptors on other cells, quercetin reduces allergic reactions more safely (no drowsiness) than many conventional drugs.

Omega-3 and Omega-6 (n-6) fatty acids constitute the two families of Essential Fatty Acids (EFAs). EFAs are considered "essential" because they are needed throughout the human life cycle, cannot be produced in the human body, and therefore must be provided through the diet. Omega-3 fatty acids help prevent an asthmatic response by limiting eicosanoid production. Consumption of gamma linolenic acid (GLA) stimulates production of prostaglandin E1 (PGE1), which dilates the bronchioles and calms inflammation.

EFAs Aid in

Maintenance of cell membrane fluidity and stability

Development and function of brain and nerve tissue

Oxygen transfer and energy production

Immune functions

Conversion into compounds involved in all body functions including local hormones governing inflammatory responses

Each 2 capsule serving of Nordic Naturals Complete Omega Formula provides:

DHA 180 mg
EPA 270 mg
GLA 66 mg
Vitamin E (d-alpha tocopherol) 30 IU
Other Omega-3s 115 mg

Complete Omega, 60 softgels Sale price $12.79 (30 servings)

Complete Omega, 120 softgels Sale Price $22.91 (60 servings)

Complete Omega 8 oz. lemon flavor, Sale Price $20.21 (48 servings)

N-acetyl-cysteine is the acetylated form of L- cysteine which is more efficiently absorbed and used form of L-cysteine. N-Acetyl Cysteine:

Can act as an antioxidant and is helpful against viruses.

Has been used as a liver protectant

Can break up pulmonary and bronchial mucus.

Can boost glutathione levels in cells

NAC may help dissolve mucus and improve symptoms associated with chronic bronchitis, asthma, cystic fibrosis and emphysema.

LE215 N-Acetyl Cysteine 600 mg. 60 caps. Sale Price $8.93

Coenzyme Q10 is an essential component of the respiratory cycle of the cell that takes place in the mitochondria and generates ATP, the cell's energy currency. Orally administered CoQ10 goes directly to the mitochondria where it

works to regulate the oxidation of fats and sugars into energy-an important function since the natural production of CoQ10 declines with advancing age. When the body has an ample amount of CoQ10 the mitochondria can work most efficiently throughout the entire body, in cells everywhere, including the most densely populated area, the heart.

Low blood levels of CoQ10 have been associated with immunodeficiency and/or an overactive (allergic) immune system.

Coenzyme Q10 has been shown to be effective against chronic inflammation of the arteries and heart muscle tissue resulting in cardiomyopathy.

Helps prevent against a recurrence of heart attacks.

UN205 Coenyzme Q10 100 mg. 30 capsules - Ultimate Nutrition $18.00

Winter Skin Care Tips

Jan. 2009

Winter Skin Care

Skin is our largest organ and our first protective layer for maintaining good health. In winter when the air holds less

moisture, this protective organ is often in a compromised state of well-being. Turning up the heat can make the internal environment even drier than the outside. In this arid environment moisture is sucked out of the skin. This happens more easily if the semi-permeable cell membranes are not well nourished, resulting in drying, cracking, flaking or swelling. Psoriasis and eczema flare ups may occur. It is important to keep skin hydrated in order to prevent pathogens from entering through dry cracked skin as well as to maintain a more youthful appearance.

Effects of Stress on Skin

Stress not only causes health problems inside the body, such as hypertension, heart disease, depression and weight gain, it has a detrimental effect on the external layer, the skin as well. Stress causes skin to look blotchy, pale and dull. Alice Lyon, a London-based medical herbalist and coauthor of "The Chinese Herbal Cookbook: Healing Foods from the East and West" (Kyle Cathie, 2000), states "Adrenaline redirects blood away from the skin and sends it to the muscles instead. This is why in times of relentless stress the skin becomes washed out." Stress can also increase signs of aging in the skin. "A 2001 study in the Archives of Dermatology reported that psychological strain-- measured anger, confusion, anxiety, depression, fatigue and tension -- can decrease the skin's ability to function normally, fight disease and heal wounds leading to wrinkled and worn-looking skin." 1

Moisturize from the Inside

Omega-3 fats such as those found in cold-water fish like salmon work on many levels to preserve skin health. When you ingest these essential fatty acids, which your body needs but cannot manufacture itself, they are incorporated into cell membranes enabling them to more effectively hold water inside the cell. The more water in the cell, the better hydrated the skin. Omega-3s also bring blood and oxygen to the skin as well as promote healthy cell growth. More specifically, EPA (eicosapentaenoic) and DHA (docosahexaenoic acid) are two powerful omega-3 fatty acids which serve as anti-inflammatory agents. "Scientists note that omega-3s are particularly valuable for protection against skin cancer and sun-induced aging."2

Americans tend to get more than enough omega-6 fatty acids in vegetable oils, except for one particular omega-6 nutrient: gamma-linolenic acid. GLA is beneficial for dry skin, but even if you consume a fair amount of vegetable oil such as safflower oil, you may not be reaping the benefits of GLA. The body uses the delta-6 desaturate enzyme to convert the oil into the active, beneficial GLA, however this enzyme is not very efficient. Therefore, it is better to obtain supplemental GLA from a source such as borage oil or evening primrose oil.

"The fat-soluble vitamin A has been touted as the anti-wrinkle vitamin. Researchers found that applying topical vitamin A (retinol) reduces wrinkles, increases collagen production, helps the skin retain water, strengthens skin and reduces sun damage."3,4

Dr. Nicholas Perricone, a dermatologist and author of The Wrinkle Cure emphasizes the importance of vitamin E with tocotrienols for skin health as it is the major antioxidant that protects fatty tissues from damage by free radicals. "The tocotrienols in vitamin E have a particular affinity for skin, offering superior protection against sunlight and other environmental stressors."5 Dr. Perricone is a big advocate of antioxidants for decreasing inflammation, a major cause of skin aging.

External Protection

To combat the effects of stress on the skin, it is best to use beauty products that help regain the healthy fluid distribution. Moisturizers that are naturally compatible with the structure of the skin are most beneficial as they are easily absorbed and used by the skin. Look for products containing rose hip seed oil and almond oil. Sunflower oil improves circulation and is an antiseptic as well. Some more extensive skin care products contain antioxidants like alpha lipoic acid (ALA) and neuropeptides.
ALA occurs naturally inside the body's mitochondria, is an antioxidant, and has an edge on other antioxidants because it is both water and fat soluble. It works on eradicating free radicals both in the cell plasma membrane and the watery interior of the cell. ALA "blocks the production of enzymes that damage the collagen fibers, preserving a smooth skin surface."6 It also signals a transcription factor AP-1 to digest damaged collagen, resulting in the elimination and erasure of wrinkles."7 Dr. Perricone states that whether you take ALA as a supplement or apply it topically in a lotion, it performs as an antioxidant while it increases cellular metabolism.

Protocol for Healthy Skin

Basically to keep skin healthy, you need to work from the inside out. Eat well. Consume a lot of "rainbow foods" rich in antioxidants. These are foods of various colors of the rainbow, like blueberries, spinach, broccoli, melons, blackberries, raspberries, and carrots. These foods rich in antioxidants help reduce inflammation. Also consume foods or supplements containing omega-3 fatty acids. Drink plenty of water to stay hydrated and use a moisturizer that will improve circulation and prevent loss of moisture.

References
1. Spehar, Christine, Natural Foods Merchandiser, Oct. 2007.p35.
2. Proceedings of the Nutrition Society, 2002.
3. Archives of Dermatology, 2007.
4. Journal of Investigative Dermatology, 2000.
5. Perricone, N. (2004) The Perricone Promise. New York: Warner.p.148.
6. Ibid. p.167.
7. Ibid p. 167.

Mega GLA with Sesame Lignans 300 mg. 60 softgels

Gamma-linolenic acid (GLA), found in evening primrose oil, borage oil, and black currant oil is an important fatty acid that plays a beneficial role in healthy prostaglandin formation. GLA (gamma-linolenic acid) is rapidly converted to dihomogamma-linolenic acid, the immediate precursor of prostaglandin PGE1 which is a potent anti-inflammatory agent.

Sale Price $12.43

For more information...

Omega Woman 120 softgels

Omega Woman provides a balanced ratio of the Essential Fatty Acids EPA, DHA, and GLA.

Each 500 mg soft gel provides:
EPA: 18 mg

Evening Primrose oil: 400 mg
DHA: 12 mg

Vitamin E (mixed tocopherols): 15 IU
GLA: 41 mg

Sale Price $15.90

For more information...

Vitamin E 400 IU 100 softgels

Ultimate Nutrition's Natural Vitamin E Complex contains all four members (d-alpha, dbeta, d-delta, d-gamma tocopherol) of

the tocopherol family of compounds, making it more nutritionally complete. This natural form of vitamin E is the most powerful and effective form of this antioxidant because it is the easiest form for your body to absorb.

Sale Price $6.60

Super Alpha Lipoic Acid 250 mg 60 caps.

One of the most unique and important qualities of alpha-lipoic acid is its ability to quench free radicals in both aqueous and lipid environments. This means that the anti-oxidant activity of alpha-lipoic acid is working in the extracellular fluid and also within the cell. Quenching free radical activity results in reduction of inflammation and hence reduces fine lines and wrinkled skin.

Sale Price $23.59

For more information...

Ultra Rejuvenex 2 oz.

Life Extension's Ultra Rejuvenex is an extraordinary youth-promoting face cream that contains green and white tea extracts, along with many other beneficial nutrients for the skin. Some key ingredients and their benefits:

Green tea extracts (antioxidant) can prevent DNA damage
Combination of alpha and beta-hydroxy acids. The beta-hydroxy acids remove dead cells at the skin's surface, without causing irritation.
Hyaluronic acid helps the skin retain moisture.
Beta-glucan is a specialized yeast cell wall extract that helps support the skin.

Sale Price $28.69
For more information...

Life Extension Mix 490 Caps.

Few people consistently eat enough plant foods to protect against common age-related decline, and commercial multivitamins do not provide all of the vital plant components needed to maintain good health. Life Extension Mix provides concentrations of the fruit and vegetable extracts that researchers have found to be protective against a wide variety of cellular insults. Life Extension Mix contains 92 unique vegetable, fruit, and herbal extracts along with high-potency amino acids, vitamins, minerals, and special antioxidants. The formula is fortified with botanical extracts that help maintain healthy cells via physiological processes separate from traditional antioxidants.

Sale Price $66.94

Probiotics: Essential for Good Health in a Clean Environment

Nov./Dec. 2008

Probiotics: Essential for Good Health in a Clean Environment

People have consumed probiotics for thousands of years, mainly in the form of fermented dairy products. The World Health Organization defines probiotics as "live microorganisms which, when administered in adequate amounts, offer a health benefit to the host."1 This beneficial effect is mainly to support a healthy immune system.

How probiotics work

Probiotics help to digest food, regulate peristalsis and bowel movements and digest protein to free form amino acids. "The digestive tract is highly permeable because nutrients must be absorbed through the small intestine into the body. Seventy percent of our immune system function takes place in the gut, and one of the ways probiotics work is through promotion of the mucosal barrier, which is a director physical barrier to pathogenic organisms." according to Taryn Forelli, N.C. an director of medical education for New Chapter supplements. In addition to establishing good colonies of friendly bacteria in the gut, probiotics inhibit the growth of bacteria, yeast and fungus (such as Candida albicans) that the immune system would otherwise have to combat. An overgrowth of candida can result in thrush and vaginal yeast infections.
Probiotics may be confused with probiotics. Prebiotics serve as a medium in which probiotics are grown. They include fructo-oligosaccharides (FOS), inulin and other fibers.

Why we need probiotics
For the general healthy population, people who are not immune-compromised, probiotics offer extra protection against bacteria. They play a more important role in the lives of the elderly, infants, people with autoimmune conditions and those who have recently taken antibiotics. Poor eating habits, chlorinated drinking water, drinking alcoholic beverages, stress and disease and the use of antibiotics in food production as well as in medical treatments can cause problems in the gastrointestinal tract by destroying good bacteria and allowing undesirable bacteria to multiply. When the ratio of good bacteria to bad is lowered, problems begin to arise such as excessive gas, bloating, constipation, intestinal toxicity and poor absorption of nutrients. Probiotics help replenish the good bacteria in the gut.

Secondly, we live in a cleaner environment than our ancestors. As a result our immune systems tend to overreact when certain microbes are introduced, unable to differentiate between dangerous pathogens and positive or neutral bacteria. Because they help build the ling of the digestive tract, they work against the immune reactions that lead to food allergies and autoimmune disease," says Udo Erasmus, author of the book Fats that Heal Fats that Kill (Alive Books, 1993).

In their book, Restoring Your Digestive Health, Jordan S. Rubin, N.M.D. and Joseph Brasco, M.D., write that some strains of L.acidophilus produce "natural antibiotics" including acidolin and acidophilin. These "natural antibiotics" target selected bacteria, not all the bacteria in the gut. They are enemies of streptococcus, salmonella, Clostridium botulinum and E. coli. Rubin and Brasco cite several studies that L. acidophilus as well as other probiotics may be effective against viruses. "In one experiment, acidolin, the antibiotic produced by L. acidophilus, demonstrated the ability to disintegrate polio and vaccine cells. In another experiment, 95 percent of herpes patients who were given L. acidophilus and L. bulgaricus saw their genital herpes disappear."3

How and when to take probiotics

Probiotics come in many different forms and there are many different strains of organisms. Generally higher potency numbers equate to better results. Dose ranges can be from 500 million to 10 billion organisms. Various delivery systems include chewable tablets, enteric coated tablets, capsules, liquids, yogurts and powders. Studies have indicated that little difference exists if probiotics are taken before a meal, after a meal, before going to bed or upon rising in the morning.

Taking a probiotic supplement is a consideration if one is experiencing gastrointestinal discomfort, has recently taken antibiotics, is elderly or immune-compromised. If symptoms persist for a prolonged period of time, the individual should consult a healthcare provider.

References
1. NFPM Sept. 2008. p.30.

2. Ibid.

3. Croatto, P. Vitamin Retailer. April 2005.p.60.

These statements are not intended to diagnose, treat, cure or prevent any disease. Consult a healthcare provider before taking any supplements.

Allerdophilus 100 caps.

TwinLab Allerdophilus is designed specially for allergic individuals. Each capsule contains a specially cultured strain of isolated (freeze-dried) lactobacillus acidophilus, dispersed in a natural psyllium seed husk fiber base. The lactobacillus acidophilus used in this product has been tested to be quite stable at room temperature over long periods of time.
Well tolerated by milk allergy sensitive individuals. Free of tablet coatings, binders and colors, No corn, soy, yeast, wheat, egg, citrus and all milk and lactose containing products.

For more information...

Advanced Formula Prozyme Digestive Enzyme Caps.

Enzymes are nature's helping hands. Food is the most abundant source of enzymes. Given that enzymes are quite fragile, they are destroyed during cooking. Consequently, insufficient amounts of enzymes are ingested. Furthermore, fast foods and highly refined foods are particularly low in enzymes necessary to replenish the body's reservoir of enzymes. Enzymes are also broken down, especially during exercise. In addition, with increasing age, the body loses its ability to produce its own enzymes to support all biochemical reactions. Thus, the decreasing supply of enzymes, be it due to poor dietary habits, stressful lifestyle, intense physical activity or aging, supplemental enzymes become essential for optimal health.
Research has shown that taking supplemental enzymes boosts the immune system, helps prevent inflammation due to wear and tear and/or repetitive motion around a joint, and keeps the blood flow normal.

For more information...

Vegetable Greens 18 oz. 64 servings

All Natural Powdered Vegetable Greens by Ultimate Nutrition. No artificial anything!
For those of you who just can't (or refuse) to get enough vegetables in your diet....
Ultimate Nutrition Vegetable Greens is a scientifically formulated combination of over 62 phytonutrients from herbal extracts, prebiotics, probiotics, plant enzymes, essential fatty acids (EFA's), super green foods, and land, sea and cruciferous vegetables.
Vegetable Greens is dairy-free and is suitable for vegetarians. It contains no artificial flavors, colors, or sweeteners, and has no hidden ingredients. Sweetened with organic maple syrup powder and stevia leaf.

For more information...

Enhanced Super Digestive Enzymes

The primary digestive enzymes are proteases (to digest protein), amylases (to digest carbohydrate), and lipases (to digest fat). These enzymes function as a biological catalyst to help break down food. Raw foods also provide enzymes that naturally break down food for proper absorption. Life Extensions Super Digestive Enzyme formula contains the following plant based enzymes:

Plant-Based Enzyme Blend
Pancreatin

Enhanced Super Digestive Enzymes 100 caps.

Protease II (from papain)

Protease III

Amylase
Lactase

     Cellulase
     Lipase
     Whole fruit papaya powder

Magnesium Deficiency Linked with Cellular Aging

A lack of magnesium accelerates aging in human cells, which may explain the link between any long-term deficiency and a higher risk of aging-related diseases, according to a new study.

Magnesium is essential for hundreds of biochemical reactions in the body. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, and keeps bones strong.

Yet research has shown that, at least in the United States, more than half the population is lacking in magnesium due to deficiencies in their diet, potentially increasing their risk of cardiovascular disease, hypertension, diabetes, osteoporosis and some cancers.

David W. Killilea and Bruce N. Ames, PhD of Children's Hospital Oakland Research Institute in California cultured human fibroblasts, which are cells that provide a structural framework for many tissues, in magnesium deficient media to which magnesium was added to provide 13 percent, 50 percent or 100 percent of the magnesium level in normal human serum. They found that although the cells survived and divided normally under moderate magnesium-depleted conditions, they appeared to become older quicker than cells grown in normal magnesium concentrations. In cultures containing reduced magnesium concentration the following occurred.

Exercise and Brain Cells, Magnesium and Cellular Longevity

Oct. 2008

Exercise Repairs Brain Damage

Recently published studies by Andrew Naylor et.al. shows that exercise can help repair damaged brain cells. Cranial radiation is often used in the treatment of childhood cancers. It is associated with cognitive impairments such as loss of memory and learning difficulty due to damage to the hippocampus, a neurogenic region of the brain.
In this study, the brains of mice were irradiated and the effects of irradiation were studied. It was noted that irradiation perturbed the structure of immature neurons and that voluntary exercise (running) significantly restored precursor cell and neurogenesis levels after a clinically relevant moderate dose of irradiation1. Also, behavioral alterations that were induced by irradiation were lessened.

Results of this study suggest that physical exercise should be evaluated in rehabilitation therapy of childhood cancer survivors. It also supports the epidemiological findings that the cognitive function of people who exercise into their golden years is often better than that of their age mates who do not get regular exercise.

Fewer cell doublings
Increased beta-galactosidase activity (a bio-marker of cell aging)
Increased loss of telomere length. Telomere malfunction has been associated with aging and development of cancer.

Killilea and Ames stated, "We are now thinking that cellular consequences of magnesium deficiency may be driving long-term chronic disease." and "You could be moderately (magnesium) deficient for a long time and not know it."2

In contemplation of these findings, there are two logical steps one can take in order to preserve cellular function into a ripe old age. Exercise and get enough magnesium in your diet. Food sources rich in magnesium include green vegetables such as spinach, beans, nuts, and unrefined grains. However, many non-organic food sources may be lacking in mineral content due to depletion of soil nutrients. Fresh organic vegetables or a dietary supplement would provide better assurance for receiving an adequate supply of magnesium.

References

1. Naylor, Andrew S., Cecilia Bull, et. al. Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. www.pnas.org/content/abstract/0711128105.Accessed Sept. 2008.

2. Killilea, David W., Ames, Bruce. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts Proceedings of the National Academy of Sciences. www.pnas/105:5768-5773;, doi:10.1073/pnas.0712401105.

Magnesium Citrate 60 mg. 100 caps.

Assimilation studies show that the citrate salt of magnesium is the best absorbed into the bloodstream. Life Extension makes a magnesium supplement that provides 160 mg of elemental magnesium in each 1000-mg capsule of magnesium citrate. This gives you the citrate salt's high bioavailability while providing adequate amounts of elemental magnesium.
For more information...

Cognitex with Neuroprotection Complex without Pregnenolone 90 softgels

Cognitex is Life Extension's comprehensive formula for: boosting brain function, decreasing mental fatigue, preserving brain cell integrity from free radical damage and lipid peroxidation in order to retard cognitive decline.

Cancer Prevention with Natural Compounds

Cancer. The word, when spoken in the same sentence along with the name of a friend or loved one often makes us hold our breath in apprehension and anxiety. Although the national report on the status of cancer indicates a decline in the cancer death rate, the decline is not shared equally among all racial and ethnic backgrounds. Cancer incidence has grown among populations who frequently consume "unhealthy" food.

According to the National Cancer Institute (NCI), scientists estimate that between 50-75 percent of cancer deaths in the U.S. are caused by human behaviors such as smoking, physical inactivity and poor dietary choices. "The NCI's Cancer Trend Progress Report recognizes certain environmental factors associated with cancer development including second-hand smoke, pesticides and dioxins.1 "While not all dioxins can cause cancer, tetracholordibenzo-p-dioxin (TCDD) likely does and can be found in dairy products, fish and meat."2 Foods that contain heterocyclic aromatic amines (HAAS) and polycyclic aromatic hydrocarbons (PAHS), toxic substances that form during food preparation under high heat, can cause DNA damage in cells. However, these substances can be removed from the body in a two step detoxification process.

A diet rich in fruits and vegetable can increase the activity of detoxifying enzymes thus decreasing the extent of DNA damage. "The antioxidant vitamins' content in such a diet also enhances the DNA protection by increasing the scavenging of radical oxidative species that occurs during metabolic ractions.3

Certain cancers are related to infectious agents that might be avoided. Worldwide as of 2002 there were 19 million cases of infectious related cancers. "D.M. Parkin states, "the principal agents are the bacterium Helicobacter pylori (5.5 percent of all cancer), the hepatitis B and C viruses (4.9 percent), Epstein-Barr virus (1 percent) , HIV together with the human herpes virus 8 (0.9).4

Clinical and epidemiologic studies suggest an association between infection, chronic inflammation, chronic illnesses and cancer. One proposal for the correlation is an "aberrant epithelial barrier that can be instigated by microbial toxins, environmental insults or the genetic predisposition of the host. Loss of epithelial integrity results in activation of resident inflammatory cells by microbial invaders or endogenous ligands."5 Another theory is that persistent inflammation leads to increased cellular turnover, resulting in the emergence of cells at high risk for malignant transformation.6 Results from numerous studies indicate that reduction of pro-inflammatory cytokines appears to be a promising approach to cancer prevention.

There are naturally occurring compounds that appear promising in cancer prevention by modulating these degenerative cellular occurrences.

Rhubarb has been used in traditional Chinese medicine for cancer treatment. The main anthraquinone from rhubarb is emodin, a compound capable of inhibiting cellular proliferation, inducing cell apoptosis (programmed cell death of bad cells), and preventing metastasis (spread of cancer cells).

Sulforaphane, an isothiocyanate derived from broccoli and other cruciferous vegetables, is know to induce phase II detoxification enzymes, disrupt cancer cell microtubule polymerization, and trigger cell cycle arrest in breast and colon cancer cells.7

Resveratrol, ellagic acid (from pomegranate), and quercitin act synergistically in bringing on apoptosis.8

Chlorophyllin, a water soluble molecule derived from chlorophyll aids in detoxification by forming tight molecular complexes with certain know carcinogens including heterocyclic amines, aflotoxin-B, and polyaromatic hydrocarbons found in tobacco smoke.

Turmeric (curcumin) has the ability to induce apoptosis in cultured cancer cells.9

Most commonly known for its time-keeping properties, melatonin is a multifaceted hormone whose many benefits are still being discovered. In clinical studies of cancer immunotherapy (treatment and prevention of cancer using the body's own immune system), melatonin has been shown to work synergistically with several of the body's own anti-tumor systems and dramatically decrease adverse effects of treatment. Dr. Paolo Lissoni, a radiation oncologist in Milan has orchestrated studies in which administration of melatonin to cancer patients effected a marked improvement in survival rate and tumor regression rates compared to patients who received chemotherapy only.10

Consumption of dietary lignans, natural plant extracts, is linked to improved breast and prostate health. When certain plant foods are ingested, the intestine converts their lignans into compounds called enterolactones, which enter the bloodstream. It is these enterolactones which may prevent against prostate cancer in men and breast cancer in women by decreasing the detrimental effects of the presence of too much estrogen and inhibiting the formation of testosterone metabolite linked with prostate discomfort (men).
In men enterolactone inhibits the aromatase enzyme that is responsible for converting testosterone into estradiol, thereby reducing the amount of excess estrogen and increasing beneficial testosterone.
"Researchers in Germany measured enterolactones and genistein levels in premenopausal women and age-matched controls. Researchers noted a decrease in pre-menopausal breast cancer risk in tandem with increased concentrations of plasma enterolactones. There was no such significant association noted with genistein."11

We may not be able to control all the risk factors for cancer. However, there is substantial evidence to support the benefits of consuming a diet rich in fruits and vegetables. We can create our own cancer prevention program in keeping our cells healthy by reducing inflammation, fortifiying cell walls from virulent and microbial invaders and warding off damage to cellular DNA. When your mother tells you to eat your vegetables, maybe you should listen.

References

1. National Report on Human Exposure to Environmental Chemicals. Centers for Disease Control and Prevention, 2005. http://progressreport.cancer.gov accessed 10/4/06.
2. Ibid.
3.Arthur, Wendy. Natural compounds assist in the battle against cancer. VR Dec. 2006. 44-5.
4. Parkin DM> The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2005 Jun15;118(12):3030-44.
5. Karin M. Lawrence T, Nizet V. Innate inability gone awry linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24;124(4):823-35.
6. Houghton, J Wang TC. Helicobacter pylori and gastric cancer: a new paradigm for inflammation associated epithelial cancers. Gastoenterology 2005 May:128(6):1567-78.
7. Arthur, Wendy. Idem.
8. Yance D. Estro-Clear Technical sheet. www.naturalhealthproducts.com accessed 10/14/06.
9. Sharma RA, Gescher AJ, Steward WP. Curcumin: The story so far. Eur J Cancer. 2005;41(13):1955-1968.
10. Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatoinin in metastic solid tumour patients with poor clinical status, Eur J Cancer. 1999;35:1688-92.
11. Piller, R, et. al. "Plasma enterolactones and genistein and the risk of premenopausal breast cancer." Eur J Cancer Prev. 2006 Jun;15(3):225-32.

Cancer Prevention with Natural Compounds

Sept. 2008

Resveratrol 100 mg. 60 veg. caps. $22.95

Resveratrol is the first natural medicinal to have solid evidence behind it showing that it blocks or stops many stages of cancer.

Dual Action Cruciferous Vegetable Extract with Resveratrol and Cat's Claw 60 veg. caps. (2 month supply) $20.40

Black Cohosh for Relief of Menopausal Symptoms

Around the middle-aged mark (although ages certainly differ and can depend on hereditary patterns), women will start noticing "the change." Menstrual cycles will start to become more infrequent or erratic. Because of hormone changes, the ever-popular "hot flashes" can be present as well, causing sweats, flushed skin and some uncomfortable nights trying to sleep. What's a woman to do?
          There are medications, hormone therapies and over-the-counter drugs available for menopausal relief, but black cohosh is becoming more popular for the suffering menopausal woman wanting to treat symptoms in a natural fashion.
          Other names for black cohosh include Squaw root, Rattlesnake root, Black root and Black snakeroot. The Latin names include Actaea racemosa and Cimicifuga racemosa. Black cohosh is a member of the buttercup family, a perennial plant that is native to North America. The herb's roots and underground stems are used in its preparations.
          According to the Office of Dietary Supplements, "Black cohosh was used in North American Indian medicine for malaise, gynecological disorders, kidney disorders, malaria, rheumatism and sore throat." It was used for other methods as well in the 19th century, and then became very popular for treating women's reproductive organ issues, including inflammation of the uterus or ovaries, infertility, threatened miscarriage and relief of labor pains.
          Many of the symptoms women experience during perimenopause are caused by the reduction of the hormones estrogen and progesterone in their bodies. Some researches believe black cohosh contains isoflavones - constituents that mimic estrogen - others suggest it somehow binds to estrogen receptors in the brain, but inhibits rather than mimics estrogen. The truth is, scientists and researches still aren't quite sure exactly how black cohosh works to reduce menopausal symptoms.
          More recently, however, black cohosh has been involved in more studies, to prove its health benefits. Remifemin by Enzymatic Therapy has been researched to show its reduction of menopausal symptoms. Remifemin is standardized to contain an equivalent of 20 mg black cohosh (Cimicifuga racemosa) root and rhizome. According to Enzymatic therapy, the estrogen-free Remifemin, "has been found to reduce symptoms of menopause by an average of 70 percent and is safe for women who cannot take estrogen." Additionally, over 90 scientific papers and 15 studies have been published on Remifemin black cohosh extract.
          A randomized, double-blind, placebo-controlled trial was done in breast cancer survivors because most of these women experience hot flashes and many use complementary or alternative remedies. The women were over age 19 and had completed breast cancer treatment at least two months before the trial; 85 women (69 of whom completed the trial) took one tablet of placebo or 40 mg/day of black cohosh (as 20 mg twice daily) for two months to determine the effect on menopausal symptoms. Fifty-nine subjects were using tamoxifen (an antiestrogen treatment for breast cancer); tamoxifen users were distributed almost equally between the treatment and control groups. The frequency and intensity of hot flashes decreased in both groups, with no statistical difference between the groups; excessive sweating decreased significantly more in the treatment group than the placebo group. Other symptoms improved equally in both groups, and scores on a health and well-being scale did not change significantly in either group.
          Some women might have adverse side effects when taking too much black cohosh, including nausea, vomiting, headache, dizziness, shaking and feeling giddy or "hyper." However, no interactions have been reported between black cohosh and prescription medicines. But it is important to discuss starting a black cohosh regimen with a healthcare provider first, especially if there have been health issues in the past.

Test Your Knowledge

1. What is black cohosh used to help treat?
a. menopausal issues
b. urinary problems
c. headaches
d. scarring, bruises and cuts

2. What is another name for black cohosh?
a. squaw root
b. black root
c. rattlesnake root
d. all of the above

3. For herbal remedies, the ____________ of the black cohosh plant is used.
a. leaves
b. roots and/or underground stems
c. flowers
d. nectar

4. According to Enzymatic Therapy's data, Remifemin has been shown to reduce symptoms of menopause by an average of _______ percent.
a. 70
b. 10
c. 20
d. 50

5. What early geographic people used black cohosh in their remedies and medicine?
a. Europeans
b. Canadians
c. Chinese
d. North American Indians

Resources and References
+Enzymatic Therapy data
+http://nccam.nih.gov/health/blackcohosh/
+http://ods.od.nih.gov
+Upton, R, ed. Black Cohosh Rhizome Actaea racemosa L. syn. cimicifuga racemosa (L.) Nutt. Standards of analysis, quality control, and therapeutics. American Herbal Phamacopoeia and Therapeutic compendium. Santa Cruz, CA. American Herbal Pharmacoepoeia, 2002:1-38.
+www.pdrhealth.com

Answers: 1.) a, 2.) d, 3.) b, 4.) a, 5.) d

Black Cohosh for Menopausal Symptoms

August 2008

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Maintaining and Restoring Joint Health

July 2008

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I often hear people accepting the cause of their joint pain and stiffness to be the aging process. However, these conditions as well as eventual osteoarthritis may be due to inadequate nutritional support for our connective tissues.

Connective Tissue Construction
Cartilage, tendons, ligaments, skin, blood vessels, and the protein matrix of bone are all examples of connective tissue. Collagen, elastin, proteoglycans and glycosaminoglycans (GAG) are concentrated in connective tissues. Collagen is the most abundant protein found in the body and is a major component of cartilage. Collagen fibers are constructed from chains of a few amino acids that are woven together to form strand-link or net-like structures. Specialized sugars are linked to the amino acids to fortify their strength. Thus, collagen is called a glycoprotein. When sugars make up more than 80 percent of the molecules in a glycoprotein, it is then called a "proteoglycan" instead. GAGs are the building blocks of proteoglycans and glucosamine is the most fundamental GAG unit.

GAG chains are found throughout the body's connective tissues. At least seven have been isolated and identified in mammalian tissues: hyaluronic acid, various chondroitin sulfates, keratin sulfates I and II, heparin, heparin sulfate, and dermatan sulfate. Pectins from fruit and alginates from marine algae are other examples of GAG.

Collagen and GAG cross-link to form unique, flexible three-dimensional web structures in connective tissues. With its propensity for polymerization, silicon is the element that makes the actual connections in the cross-linking.1 Supplemental glucosamine and especially chondroitin may be providing bioavailable silicon to cartilage. Suboptimal silicon intake could be a major reason why arthritis develops, or a sports injury fails to heal completely.

Natural Alternatives to Anti-inflammatory Medications
Typically arthritis, tendonitis, and conditions such as chronic sports injuries are treated with rest, possibly weight loss, and anti-inflammatory pain medications such as aspirin, NSAIDs (non-steroidal anti-inflammatories) or steroids such as cortisone to reduce inflammation. Two serious problems with drug approaches are that drugs cannot physically repair the damaged connective tissue, and anti-inflammatories are not safe for long term use. Alternatively, pain in an arthritic joint can be reduced by (1) restoring some of the cushioning of healthy cartilage and (2) reducing the existence and/or production of inflammatory prostaglandins (type E2).

Glucosamine and Chondroitin
Research studies concur that supplementing glucosamine, chondroitin, or a combination of both on a relatively long-term basis can reduce pain and improve mobility in degenerative joint disease with no risk of dangerous side effects.2-4 Compared to ibuprofen, glucosamine's effectiveness at controlling both pain and inflammation was dramatically better.

Chondroitin sulfate is a glycosaminoglycan and a natural body lubricant providing protection for bones from rubbing against each other. Like glucosamine, it is an important component of the body's natural building blocks for the cartilage found in joints. Chondroitin sulfate is difficult to find through the diet as its primary source is animal cartilage such as the trachea of cows, pigs and chickens. Therefore, supplementation is often the most common way of increasing levels of this nutrient in the body.

Omega-3 Fatty Acids
Omega-3 fatty acids form the building blocks of many of the body's natural anti-inflammatory compounds. Fish oils are a better source of omega-3 fatty acids than plant-derived omega-3 sources as fish oil contains the longer chains of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) whereas plant-derived sources (such as flax seeds) contain the shorter chain fatty acid alpha-linolenic acid. Fish oil supports the body's natural anti-inflammatory response and can reduce joint pain and swelling. Within joint and muscle tissue, EPA stimulates the production of beneficial eicosanoids that naturally reduce inflammation. Although it may take a few days or weeks to feel a lessening of symptoms, fish oils have proven to be a healthy and effective choice with no adverse side effects. Research shows it is best to begin with therapeutic amounts of fish oil, about 2-3 grams of EPA and DHA, and then later reduce the amount for maintenance.

When embarking any recovery program it seems logical to supply your body with what it is lacking with a natural source. These naturally occurring supplements - glucosamine sulfate, chondroitin sulfate and the omega-3 essential fatty acids- would be a good option to try first.

As with any nutritional supplement, one should consult a health care professional before taking something new. Fish oils have many benefits, but may not be recommended for individuals who take blood thinners.

References
1.Broadhurst, C. Glucosamine & Chondroitin: Nutritional support for Cartilage. Vitamin Retailer. Mar. 2003 p54.
2. Matheson AJ, Perry CM (2003), Glucosamin: a review of its use in the management of osteoarthritis. Drugs and Aging 20, 1041-1060.
3. Richy F, Bruyere O, Ethogen O, et al. (2003). Structural and symptomatic efficacy of glucosasamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine 163, 1514-1522.
4. Kelly GS (1998). The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review 3, 27-39.

Glucosamine Chondroitin & MSM

Ultimate Nutrition's product containing three nutritients that have been proven effective for joint health.

Glucosamine- an amino sugar normally produced in the human body. It is necessary for the construction and repair of connective tissue and healthy joint cartilage.

Chondroitin sulfate also occurs naturally in the body. Like glucosamine, chondroitin is a building block of proteoglycans: large protein molecules that give cartilage elasticity.
Chondroitin sulfate acts by attracting fluid into the proteoglycan molecules and stimulates collagen production, an ingredient that forms part of the cushioning structure at the ends of the joints.

Methyl Sulfonyl Methane (MSM) is a nutritional form of sulfur. MSM acts as a transport molecule for elemental sulfur, which is required for the amino acids methionine and cysteine.

UN232 Glucosamine Chondroitin& MSM 90 tablets $8.14

ArthroMax with Fruitex B

Life Extension's Arthromax combines the following potent nutrients into one convenient joint-protecting formula.

Glucosamine provides the underlying structural foundation for joints, while methylsulfonylmethane (MSM) provides crucial sulfur compounds that are so important to maintain comfortable joint function.
Nobiletin is a citrus flavonoid that has demonstrated potent effects in suppressing destructive cytokines such as tumor necrosis factor alpha and interleukin-1 beta. In addition, nobiletin has demonstrated natural COX-2 inhibiting properties without affecting beneficial COX-1. Suppression of the COX-2 enzyme limits the production of joint damaging prostaglandin E2. A special Boswella extract known as 5-Loxin® inhibits the 5-lipooxygenase enzyme, reducing levels of joint damaging leukotriene B4.
ArthroMax™ has been enhanced with FruiteX B® OsteoBoron™, a patented form of boron that is chemically identical to the natural plant forms of boron found in food. Considered safer and more bioavailable than other forms of boron, FruiteX B® OsteoBoron™ not only supports strong bones but healthy joints!

LE903 ArthroMax with Fruitex B 120 capsules $26.96

Omega-3 Formula

Fish oil is the most concentrated source of the omega-3 fatty acids EPA and DHA. A secondary source is alpha-linolenic acid (ALA), which is found in flaxseed, walnuts, and canola oil. However, only 10% of ALA ingested from food is converted into active EPA or DHA; much of it is simply burned for

calories. Nordic Naturals' Omega-3 Formula provides an excellent source of Omega-3 fatty acids in their naturally existing ratios. EPA (eicosapentaenoic acid and DHA (docosahexaenoic acid), the two main components of Omega-3 from fish oil, are essential for growth and development throughout the human lifecycle. Advanced lipid antioxidants have been added for freshness along with a delicious natural lemon taste.

Nordic Naturals Omega-3 Formula 60 caps. $11.21 or 120 caps. $20.21

Super Omega-3 EPA/DHA

Life Extension's Super EPA/DHA contains the "healthy trio" of concentrated nutrients from fish oil, sesame seed oil and extra virgin olive oil. Super Omega-3 EPA/DHA with Sesame Lignans & Olive Fruit Extract contains twice as much EPA and DHA as conventional fish oil capsules.

Each capsule contains:

350 mg EPA

250 mg DHA

50 mg other Omega-3 fatty acid

150 mg Polyphen-Oil™ Olive Fruit Extract

5 mg Sesame seed lignan extract

Super Omega-3 EPA/DHA 120 softgels $24.00

Maintaining Healthy Bones

June 2008

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Most bone is formed during youth, when the body is growing and osteoblasts work overtime to lengthen bones. Bones stop lengthening when we reach our maximum height, which for women usually occurs in the teens but for some men may continue well into their twenties. Men's bones will continue to add mineral content until around age 30, increasing in density to provide strength. After this point, called peak bone mass, bones will slowly decline in strength. Throughout life, factors including heredity, hormones, diet, exercise, and certain medications affect bone density.

The human skeleton is in a constant state of construction. As soon as bone is built, it is quickly torn down to make way for the construction of new bone. This process continues in a constant cycle because the body has two different cells that form bone: osteoblasts and osteoclasts. Osteoblasts are the cells that make bone mineral, while osteoclasts are the cells that tear it down.

As our bodies age, this fine balance is lost. As the relative hormone levels shift in midlife-more drastically in women than in men-the osteoclasts gain the upper hand and bone mass begins dwindling away. Some bone is already being lost by the time women reach menopause, but the rate of loss can increase as much as tenfold during the first six years after menopause. This is the essence of type I osteoporosis.

From midlife onward, bone health is threatened by overactive osteoclasts. To add to the problem, the osteoblasts may become less active from age 60 onward, thus causing type II osteoporosis.

Osteoporosis is a debilitating bone disease characterized by low bone mass and deterioratoin of bone tissue, leading to greater bone fragility and an increase in fracture risk.

Osteopenia is a decrease in bone mineral density that often leads to osteoporosis. Osteoporosis is considered a silent disease because it can develop slowly over the course of many years and may go undetected until one suffers a fracture or vertebra collapse.

Risk Factors to Bone Health

A high-phosphorus diet-epitomized by a fast-food hamburger and soft drink-causes a calcium-phosphorus imbalance that favors osteoporosis.

Age itself is a factor for bone health. Hormonal balance changes with age, as levels of bone-protecting sex hormones decline, more precipitously in women than in men. The hormonal form of vitamin D-1,25-dihydroxyvitamin D-declines, as do melatonin and dehydroepiandrosterone (DHEA). Cortisol and parathyroid hormone increase with age. Hormones such as testosterone, estrogen, and progesterone generally favor bone maintenance, as do vitamin D, DHEA, and melatonin. The thyroid, parathyroid, and glucocorticoid hormones (such as cortisol) favor bone destruction.1 Doctors prescribe glucocorticoids for multiple reasons, including arthritic problems, asthma, and inflammatory bowel syndrome.

A common reason people developing brittle bones is from excessive alcohol consumption.

For men testosterone works by improving bone thickness, especially in the small bones of the spine. In women, estrogen and progesterone assist in bone maintenance. Spinal fractures are much more common in men than in women. Moreover, men with low testosterone are twice as likely as women to suffer a hip fracture.

One of the most important things people can do to increase bone mass is to maintain an active lifestyle that incorporates weight-bearing activity. The term "weight bearing" refers to activities that make the skeleton bear the body's weight. Certain cells located at the joints and different parts of the bone sense motion and stress, and respond by stimulating bone-forming cells to create stronger bone.

Two common recommendations for preventing osteoporosis and osteopenia are ensuring sufficient dietary intake and absorption of the minerals calcium, magnesium and phosphorous, the structural componenents of bone and engaging in weight-bearing exercise. Some other nutrients that effect bone mineralization are zinc, boron, copper, fluoride, manganese, silicon, and vitamins D and K.

Calcium- Provides bone with mechanical strength, supplemental calcium serves as a reservoir that can be tapped if calcium loss exceeds calcium intake. Calcium absorption decreases as the amount of calcium consumed at one time increases. Therefore, it is best to take two or three daily doses of less than 500 mg. per dose.

Vitamin D
Vitamin D promotes bone formation and mineralization and is needed for the absorption of calcium and phosphorous from food. It can be obtained naturally in a few foods such as catfish and salmon and in fortified foods.. It is synthesized in the skin upon exposure to ultraviolet rays of sunlight. The current recommended intake for vitamin D is 5 to 15 mcg or 200 to 600 IU for people 19 and older2. However, there remains much controversy over this as some scientists recommend high level- 1000 IU per day for those not getting enough sunlight.3

Vitamin K
Vitamin K includes K1 (phylloquinone or phytonadione) and K2 (menatetrenone, menaquinone). K1 is the major dietary form of vitamin K. K2 is found in some foods and is produced by bacteria in the intestines. "Studies indicate that vitamin K2 may stimulate bone formation and suppress resorption.4

Magnesium
About half the body's magnesium stores are found in bone. Magnesium deficiency has been related to osteoporosis

References

1. Huemer, Richard MD, How Calcium Combines With Other Nutrients to Combat Bone Loss. LE Magazine 2005.
2. Food and Nutrition Board. Institute of Medicine. Dietary reference intakes for calcium, phosphorous, magnesium, vitamin D and fluoride. Washington, DC National Academy Press, 1997. http://www.nap.edu/openbook.php?isbn+0309063507
3. Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. AM J clin Nutr 2004;79:362-71.
4. Iwamoto J, et al. Effects of vitamin K2 on osteoporosis. curr Pharm Des 2004;10(21):2557-76.

Bone Restore

A great supplement from the Life Extension foundation providing the following ingredients per 5 capsules:

Vitamin D3 (as cholecalciferol) 1000 IU
Calcium (as dicalcium malate, calcium bis-glycinate, calcium fructoborate)

1200 mg
Magnesium (as magnesium oxide) 340 mg
Zinc (as zinc amino acid chelate) 2 mg
Manganese (as manganese amino acid chelate) 1 mg
Boron (calcium fructoborate as patented Fruitex B® OsteoBoron™)
3 mg
Silicon (from horsetail herb, Equisetum arvense) 5 mg
Bone Restore 150 tabs (1 month supply)

Your price $15.19

Calcium Citrate with Vitamin D3

A superior "basic" calcium supplement containing highly absorbable form of calcium citrate. Calcium is more effective when taken in smaller doses spread throughout the day and before bedtime. When taken at night, it also promotes a sound sleep. The citrate salt of calcium has been documented to be well absorbed and utilized by the body. Vitamin D is necessary for both the efficient absorption of dietary calcium and phosphate, as well as their metabolism once ingested.

Calcium Citrate with Vitamin D3 300 caps. (up to a 10 month supply) Your price $16.20

Super Vitamin K with K2

Vitamin K regulates the body's calcium and promotes bone calcification.

Vitamin K1 is obtained in the diet primarily from dark leafy vegetables (lettuce, spinach, and broccoli). Unfortunately, vitamin K1 is tightly bound to the chlorophyll in green plants, thus, aging humans are not always able to benefit from ingested K1-containing plants.
Vitamin K2 is found in only small quantities in the diet, primarily in dairy products. Human studies show that vitamin K2 is absorbed up to ten times more than K1. Vitamin K2 remains biologically active in the body far longer than K1.

Super Vitamin K with K2 90 softgels (3 month supply) Your price $18.19

Mineral Formula for Men Mineral Formula for Women

The forms of calcium and other minerals in Mineral Formula for Women and Men have been shown to maintain bone density better than the standard forms of calcium used in most commercial calcium supplements. Vitamin D is included to aid in calcium absorption and utilization.

Each capsule contains:

Vitamin D (as cholecalciferol): men - none/women 100 IU
Calcium (as calcium citrate malate, and succinate) Men 31 mg/ women 123 mg
Magnesium (as magnesium oxide and amino acid chelate): men 286.1 mg/ women 100 mg
Manganese (as manganese gluconate): men 0.5 mg/ women 0.25 mg
Potassium (as potassium aspartate): men and women 8.05 mg

Serving suggestion: 1 capsule per day in addition to your daily multivitamin supplement.

Mineral Formula for Men 100 caps. $10.13

Mineral Formula for Women 100 caps. $10.13

Maintaining a Healthy Prostate

April 2008

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Prostate health is not a subject of light conversation, but it is something every man needs to pay attention to. Whether you are a man in your early 20's or someone in the senior years of 70 or more, the following information may be helpful for a long and healthy life.

Maintaining a Healthy Prostate

There are a number of health problems that can affect a man's prostate gland. Three of which are benign prostatic hyperplasia (BPH), prostatitis and prostate cancer.

BPH is a non-cancerous disorder common to older men. It develops when the prostate gland enlarges during the aging process. It is common for men to first notice symptoms around age 45. Since the prostate gland surrounds the urethra, an enlarged prostate can increase the frequency and urge to urinate and may interfere with complete emptying of the bladder.

Numerous large studies show that saw palmetto extract (most commonly in the amount of 320 mg daily) improves urinary function in men with BPH.¹ Saw palmetto's benefits in relieving BPH appear connected to reduced inflammation and lessened conversion of testosterone into dihydrotestosterone. This herb does not interfere with the diagnosis of prostate cancer since PSA (prostate specific antigen, a marker used to map the health of the prostate gland) levels are not altered during supplementation with saw palmetto.

Another option for easing symptoms of BPH is beta-sitosterol, a special type of fat that occurs in numerous plants, particularly peanuts. A review of four studies, covering 519 men, concluded that beta-sitosterol improves urinary symptoms.²

Prostatitis refers to an inflamed prostate. If you have prostatitis, you may have:

Ø Pain or burning when you urinate.

Ø Urinary urgency or frequency.

Ø Fever and fatigue; flu-like feeling.

Ø Pain in the prostate gland, lower back, or genital area.

Ø Painful ejaculation.

Bacterial prostatitis can be diagnosed by a urine culture to look for bacteria. Acute bacterial prostatitis usually originates in the prostate, but sometimes, the bacteria can spread there from the bladder or urethra.

Approximately one in six men will be diagnosed with prostate cancer sometime in his lifetime. The earliest stages of the disease are virtually without symptoms, although the prostate-specific antigen (PSA) blood test indicates that cancer may be growing in the prostate gland. How quickly a man's PSA level rises from year to year is more important than the actual PSA score itself. Many urologists recommend that a man have a baseline PSA level taken when he is in his thirties and then begin annual screenings when he reaches 40.

Nutritional Insurance for a Healthier Prostate

Several nutritional supplements have been shown to decrease the risk of developing prostate cancer.

Lycopene- A member of the carotenoid family and a powerful antioxidant. Found in tomatoes, most beneficial when cooked. "One study found that eating tomato-based foods at least five times a week slashes a man's risk of prostate cancer by 40 percent."³

Pomegranate Juice- contains extraordinary amounts of antioxidants and has anti-inflammatory effects. One study done by UCLA researchers took 50 men who just had surgery or radiation treatment for prostate cancer. The men showed increases in PSA after their treatment. In the study the subjects drank 8 oz. of pomegranate juice daily and were able to lengthen their PSA doubling time from 15 months to 54 months.⁴

Green Tea has been shown in animal studies to prevent or slow prostate cancer

A precursor to prostate cancer is a condition called prostate intraepithelial neoplasia (PIN) which is the presence of abnormal prostate cells that are likely to turn cancerous at some time in the future. "Double -blind research found that, in a group of 60 men with high grade PIN, daily supplements of green tea catechins (600 mg per day) significantly reduced the number of men who went on to develop prostate cancer."⁵

Prostate health can be favorably (or unfavorably) effected by what a man eats. Adding several health-promoting foods and/or supplements to one's diet may very well add to a longer healthier life.

References

1. Wilt T, Ishani A, Mac Donald R. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev 2000;3:CD001043.

2. Wilt T, Mac Dondald R, Ishani A, et al. Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev 2000;2:CD001043.

3. Santillo VM, Lowe FC. role of vitamins, minerals and supplements in the prevention and management of prostate cancer. Int Braz J Urol 2006;32(1)3-14

4. Toews, Victoria Dolby. Ingredients for a Healthy Prostate. NIE Magazine Jan/Feb 2008;47.

5. Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006;66(2):1234-40.

Saw Palmetto Soft Gels

Saw palmetto berries contain of a volatile oil, which holds a variety of fatty acids, and is high in phytosterols. These ingredients not only control the conversion of testosterone to DHT but also block its binding to the prostate cells, which reduce the levels of inflammation and minimize the risk of prostate enlargement. Importantly, saw palmetto also has anti-estrogenic and anti-androgenic effects in addition to anti-inflammatory properties.

Ultimate Nutrition incorporates the highest quality standards in sourcing raw materials, manufacturing and packaging to ensure the finest supplements available.

Saw Palmetto 100 Softgels Your price $6.60

Pomegranate Extract

Based on the unique vascular benefits of pomegranate and cocoa polyphenols, these two beneficial nutrients have now been combined into one low-cost supplement.

Life Extension determined punicalagins to be the most significant constituent in pomegranate. This research has led LEF to suggest a daily intake at least 78 mg of punicalagins for optimal cardiovascular health and 280-375 mg for optimal prostate health.
Chocolate contains a wide range of antioxidant compounds called polyphenols, including the procyanidins epicatechin and catechin. Research has shown that cocoa contains more antioxidant polyphenols than any other food.

Pomegranate Extract with Cocoa Gold 30 veg. caps. on sale at $15.30

Ultra Natural Prostate

Ultra Natural Prostate with 5 Loxin and Standardized Lignans contains the most scientifically substantiated plant extracts (lignans) to alleviate prostate discomfort, plus lycopene and boron to help protect the prostate and maintain its healthy function.

The eight other active ingredients in the new Ultra Natural Prostate Formula are:

5-LOXIN™ boswellia extract.
Nettle root extract (Urtica dioica)
Saw palmetto extract
Pygeum
Beta-sitosterol
Cernitin®
Boron
Lycopene

Ultra Natural Prostate with 5-Loxin and Standardized Lignans (one month supply) on sale at $24.22

Green Tea Extract

The active constituents in green tea are polyphenols, with an antioxidant called epigallocatechin-3-gallate (EGCG) being the most powerful. The antioxidant activity of EGCG is about 25-100 times more potent than vitamins C and E. One cup of green tea may provide 10-40 mg of polyphenols and has antioxidant effects that are greater than a serving of broccoli, spinach, carrots, or strawberries.

Published research shows that EGCG is the most potent cancer cell suppressing polyphenol found in green tea.

The botanical extract in Life Extension's Mega Green Tea Extract has been concentrated and dual standardized to ensure the highest quality, consistency and biological activity. This advanced extract contains 98% total polyphenols (710.5 mg per capsule) and 45% Epigallocatechin gallate (EGCG) (326.25 mg per capsule).

Mega Green Tea Extract 100 veg. caps. on sale at $22.95

L-Theanine: Aid for Stress-Damage Reduction

March 2008

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The negative effects of stress are profoundly coming to be known as underlying causes of many facets of ill-health. Stress plays a role in eveything from high blood pressure to high cholesterol, heart disease and more.

In this month's newsletter we take a look at one naturally occuring component of tea that can reduce many of the effects that stress can have on our bodies.

Theanine: Aid for Stress-Damage Reduction

Health benefits have been attributed to tea consumption since the beginning of recorded history about 50 centuries ago in Southeast Asia. Tea has become the most widely consumed beverage in the world aside from water and is now cultivated in over 30 countries worldwide.

Although tea has been revered for its healthful properties since ancient times, only in recent decades have scientists seriously endeavored to unravel tea's chemical secrets. This research has confirmed what folk healers have long claimed: tea both calms and invigorates, while protecting against various ailments and even contributing to a longer, healthier life.

Scientific research into the health effects of tea since 1980 have focused on the importance of a family of related compounds called polyphenolic flavonoids, including catechins, that have been associated with a whole array of biological activities, including antibacterial, anticancer, anti-inflammatory, antiviral, blood-sugar-helping and cholesterol-lowering effects.

There are four primary polyphenols in green tea- epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC) and epigallocatechin gallate (EGCG)-with EGCG regarded as a significantly more powerful antioxidant.

In addition to EGCG, green tea contains other compounds with equally beneficial bioactive properties. One lesser known but no less important of these compounds is an amino acid called theanine.

Calming Properties

Theanine accounts for up to 50% of the dry protein weight of green tea.¹ Of course, tea also contains caffeine, a familiar stimulant. Theanine is credited with counterbalancing caffeine's stimulating effect by inducing relaxation. The precise mechanism by which theanine produces this anxiety-reducing effect remains uncertain, though theanine is known to alter levels of two important mood-regulating neurotransmitters, dopamine and serotonin.^2,3Unlike caffeine, theanine increases GABA (gamma-aminobutyric acid), an inhibitory neurotransmitter that not only induces relaxation but also produces a sense of well-being. Just as meditation, massage, or aromatherapy quiets the mind and body, so too theanine plays a role in inducing the same calm and feeling of well-being.

Relaxing Effects

Theanine has also been shown to reduce high blood pressure, further evidence that it induces relaxation.3,4 Japanese researchers, for instance, have demonstrated that theanine reduces blood pressure in a dose-dependent manner in rats serving as a model for human hypertension (elevated blood pressure). The larger the dose of theanine given the rats, the more dramatic was the reduction in their blood pressure. Intriguingly, when control rats with normal blood pressure were given the highest dose of theanine, they experienced no change in blood pressure. It appears that theanine has no effect of lowering blood pressure in normal individuals, but instead affects blood pressure only when a problem already exists.^2,4

Conclusion

Theanine is clearly one of nature's remarkably beneficial compounds. While it is possible to ingest enough green tea daily to consume therapeutic doses of theanine, it may be more convenient to reap the benefits of this natural health enhancer by taking supplemental theanine in capsule form. Many health care practitioners suggest 200 mg taken twice daily for optimal health benefits.

References

1. Kamath AB, Wang L, Das H, Li L, Reinhold VN, Bukowski JF. Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6009-14.

2. Yokogoshi H, Kobayashi M, Mochizuki M, Terashima T. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res. 1998 May;23(5):667-73.

3. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylmethylamide in spontaneously hypertensive rats. Life Sci. 1998;62(12):1065-8.

4. Yokogoshi H, Kato Y, Sagesaka YM, Takihara-Matsuura T, Kakuda T, Takeuchi N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci Biotechnol Biochem. 1995 Apr;59(4):615-8.

L-Theanine

The Life Extension Foundation has formulated this product with 100 mg. of this unique ingredient to provide a safe and natural supplement to help you get through your day in a more calm state of being.

L-Theanine 100 mg. 60 caps. Sale price $16.20

Natural Stress Relief

Life Extension has combined L-theanine and lemon balm into a new formula called Natural Stress Relief.

Lemon balm (Melissa officinalis), a plant native to the Mediterranean region, has been clinically provento reduce anxietyby 49% and sleeplessness by up to 39% in as little as 15 days.What's more, lemon balm produces these calming effects while also enhancing memory and attention.
Theanine induces relaxation without causing drowsiness. In fact, studies show that theanine enhances the brain's ability to concentrate, learn, and remember.

Natural Stress Relief 90 vegetarian caps. Sale price $18.90

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February is heart health month. You don't need to wait until Valentine's day to take care of your heart and those of your loved ones. Here are some helpful hints to keep your ticker going strong for many years to come.

Supplements to Boost Heart Health

Does a healthy person who gets regular exercise and eats a fiber-rich diet need additional nutrients to ensure a healthy heart? Most likely the answer is yes. Unfortunately a lot of people do not get sufficient nutrients supplied by their diet. In addition, some nutrients are depleted by medications such as statin drugs used to treat cardiovascular problems. The following is a list of beneficial supplements chosen by some top doctors in the fields of naturopathy and cardiology.

Coenzyme Q10

Studies show that the energy carrier CoQ10 helps treat congestive heart failure and heart arrhythmias, lowers blood pressure and prevents the oxidation of low-density lipoprotein cholesterol (the "bad" kind). Also, a side effect of taking cholesterol-lowering statin medications is lower CoQ10 levels (Journal of Hypertension, 2007; Clinical Cardiology, 2004). This results in fatigue and muscle pain.

Omega-3 Fatty acids (fish oil)

Research shows that omega-3 fatty acids in fish reduce blood triglycerides, reduces inflammation in blood vessels thereby preventing the formation of arterial plaque and mildly reduces blood pressure.

Look for an oil supplying 700 to 750 mg of EPA and DHA.

D-ribose

This unique form of sugar is a building block of ATP, adenosine triphosphate, the fuel that powers the body's cells, including the heart. It has also been found to increase the energy of people with chronic fatigue and fibromyalgia. In studies of healthy athletes as well as those who have suffered injury to the heart muscle, supplying fatigued muscle cells with D-ribose quickly restored ATP levels to normal.^1,2

L-Carnitine

Carnitine is a naturally occurring amino acid found in dairy and red meat that is critical for converting fatty acids into fuel. Muscles, including the heart, plus the kidney, and the liver depend heavily on fatty acids for fuel. Carnitine functions as a carrier system for fatty acids, shuttling them into mitochondria so they can be oxidized. L-carnitine helps people with fatigue and muscle weakness, including heart failure or arrhythmias, according to Mark Stengler, N.D. a naturopath in La Jolla, CA and Dr. Glen Rothfeld.³

Hawthorn

Studies show that extracts of hawthorn berries, leaves and flowers help lower blood pressure, improve blood flow through coronary arteries and treat congestive heart failure (British Journal of General Practice, 2006; The American Journal of Medicine, 2003).⁴

Niacin

This B vitamin may well serve the heart better than statin heart medications: Niacin lowers LDL cholesterol, raises HDL cholesterol (statin drugs do not), and lowers lipoprotein (an independent risk factor for cardiovascular disease that no drug addresses)⁵ says Ryan Bradley, N.C., who developed the Diabetes and Cardiovascular Wellness Program at Bastyr Center for Natural Health in Seattle, WA.

Magnesium

This common mineral stabilizes cardiac conductivity, and can reduce blood pressure by relaxing the smooth muscles within the blood vessels. Lower blood levels of magnesium have been associated with higher risk of heart attack.

Pomegranate juice

This dark red juice is rich in antioxidants. It lowers blood pressure and prevents LDL cholesterol from oxidizing (Clinical Nutrition, 2004) "Oxidized LDL promotes atherosclerosis even more than just high LDL by itself," says Bradley. Studies noted in Journal of Cardiology, 2005 show that pomegranate juice improves blood flow to the heart.

Taurine

Taurine helps people with congestive heart failure and arrhythmias. Ryan Bradley states "We do know that people with reduced blood flow to the heart have lower taurine concentrations in their blood." "I've had dramatic success with taurine improving patients' hear rhythms, reducing heart rates and improving exercise tolerance."⁶

As with all medications or supplements, please consult your health care provider before taking any supplement. More information is available on these safe supplements on our website www.health-n-sport.com.

References

EMBO Rep. 2006 Mar;7(3):276-82.

Am J Physiol. Regul Integr Comp Physiol. 2004 Jan;286(1):R182-8.

Bond, P. Natural Foods Merchandiser, Dec. 2007, p.42.

Ibid.

Coenzyme Q10

CoQ10 is required to convert fats and sugars into cellular energy, yet the natural production of CoQ10 declines precipitously with advancing age.

Coenzyme Q10 is incorporated into the mitochondria of cells throughout the body where it facilitates and regulates the transformation of fats and sugars into energy. A large body of scientific evidence shows that CoQ10's ability to restore mitochondrial function has a profound effect on one's overall health.

As people age, their natural synthesis of CoQ10 slowly declines. When people take "statin" cholesterol lowering drugs, CoQ10 synthesis can be reduced even further.

UN205 Ultimate Nutrition CoQ10 100 mg. 30 caps. $16.20

Sale Prices listed below

LE1264 Life Extension's Super Ubiquinol 50 mg. 30 softgels $13.50

LE1252 Life Extension's Super Ubiquinol 50 mg. 100 softgels $39.15

Omega-3 Fish Oil

Nordic Naturals' Omega-3 Formula provides an excellent source of Omega-3 fatty acids in their naturally existing ratios. EPA (eicosapentaenoic acid and DHA (docosahexaenoic acid), the two main components of Omega-3 from fish oil, are essential for growth and development throughout the human lifecycle.

Strong science has contributed to healthy gains for the fish oil marketplace, as the benefits of Omega-3 fatty acids for a "healthy heart" attract more attention in the medical community. In fact, the federal government is in progress of reviewing a health claim that may further expand the fish oil supplement market as a functional food.

NO215 Nordic Naturals Omega-3, natural lemon flavor 8 fl. oz. $17.77
NO213 Nordic Naturals Ultimate Omega 120 softgels $34.87
LE982 Life Extension Super Omega-3 EPA/DHA 120 softgels $22.80

NO208 Nordic Naturals Omega-3 60 caps. $10.64

D-Ribose

D-ribose, a carbohydrate molecule found in every living organism, facilitates the production of ATP, the primary source of energy for all cellular processes.

Healthy, active cells constantly replenish their supply of ATP to produce vital cellular energy. However, under conditions of stress, injury, or aging, critical body tissues such as heart and skeletal muscles cannot produce ATP quickly enough to perform optimally.

D-Ribose can help speed energy recovery, increase energy reserves, and maintain healthy energy levels in heart and muscle tissue.

Geranium
A test of essential oils against different methicillin-resistant staph bacteria found that a combination of grapefruit seed extract and geranium oil had the greatest antibacterial effect against MRSA, while geranium and melaleuca alternifolia were the most active against methicillin-sensitive S. aureus (Oxford strain).3

Sale price

LE972 D-Ribose Powder 150 grams (30 servings)

$19.60

Natural Antibiotics Part 2: Essential Oils

January 2008

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Essential Oils

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In this month's newsletter we extend the topic of natural antibiotics to include essential oils. These fragrant concentrated plant extracts have many practical uses. Many have remarkable antibacterial properties. Keeping your home and your body germ-free can be easier and safer with 100% pure essential oils.

Try some today!

Natural Antibiotics: Part 2

Last month we discussed the use of grapefruit seed extract as an effective natural antibiotic. In this month's issue we focus on the use of essential oils and a common cleansing agent as natural antibiotics and germicides.

An essential oil is a concentrated hydrophobic liquid (a substance that has an aversion to water) containing volatile aromatic compounds extracted from plants. While essential oils have been known and used for thousands of years, it has only been since the 1930's that medical researchers around the world have documented their antimicrobial effects. Because of the complexity of the chemical components found in essential oils, super germs find it difficult to build resistance to them. Dr. Jean Valnet, a prominent French physician of the 1950's and author of The Practice of Aromatherapy, wrote "Infectious microbes do not appear to become accustomed to the essential oils as they do to the many forms of treatment using antibiotics."

In a research study done by Prabuseenivasan et.al., 21 essential oils were screened against four gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris) and two gram-positive bacteria Bacillus subtilis and Staphylococcus aureus at four different concentrations. Nineteen of the 21 oils showed antibacterial activity against one or more strains. Cinnamon, clove, geranium, lemon, lime, orange and rosemary oils exhibited significant inhibitory effect. Cinnamon oil showed promising inhibitory activity even at low concentration.¹

Some essential oils have been shown to kill super germs like MRSA (methicillin-resistant Staphylococcus aureus).

Tea Tree (Melaleuca alternifolia):
One study tested melaleuca against 66 isolates of Staphylococcus aureus, 64 of them methicillin- resistant. All 66 isolates were susceptible to tea tree oil.2

OreganoThe powerful constituents carvacrol and thymol are deadly against MRSA. According to an Italian study, both methicillin-sensitive and methicillin-resistant S. aureus are inhibited by these constituents. 4 Researchers at Georgetown University Medical Center tested and concluded that oregano essential oil and monolaurin, a form of fatty acid found in human and coconut milk, alone or combined with antibiotics might prove useful in the prevention and treatment of severe bacterial infections, especially those that are difficult to treat and/or are antibiotic resistant.5

Cinnamon Bark and Clove
Staph bacteria produce dangerous enterotoxins which can cause toxic shock. A study at Queen Margaret University in Edinburgh found that cinnamon and clove oils decreased the production of enterotoxins A and B.6

Mountain Savory
This essential oil also has thymol and carvacrol so its germ-killing ability is similar to that of oregano. It has been shown to be active against E. coli, MRSA and the yeast Candida albicans.7

Eucalyptus
Eucalyptus oil is antibacterial, antifungal, antimicrobial, antiviral, anti inflammatory and decongestant in nature which makes it a good ingredient for many medicines for treating respiratory problems. A study published in Laryngoscope in 2004 shows its usefulness in treating non-bacterial sinusitis.

Practical applications of essential oils:

Sanitizing floors and countertops:

For washing floors, add 8-10 drops tea tree oil along with your favorite biodegradable liquid dish detergent to 4 gallons of hot water.

Countertops: 3 drops tea tree oil to a wet paper towel. Wipe down all surfaces.

Cleaning the bathroom: add 5 drops of tea tree oil to 24 oz. water in a spray bottle. Spray on bathroom commode and sink. Allow to dry.

Respiratory infections:

Topically apply a mixture of 3 drops of eucalyptus oil in approximately 1 oz. of carrier oil, such as fractionated coconut oil, to chest area. For added comfort and effectiveness, apply a warm moist compress.

Internally: 3-5 drops of oil of oregano in 4 oz. of juice or Oregacyn capsules 2-3 times daily whenever you feel a cold coming on.

Here is a great tip from Dr. Isadore Rosenfeld, one of America's most trusted medical doctors on the treament of ear infections. In his book, Dr. Isadore Rosenfeld's 2005 Breakthrough Health, he tells of the effectiveness of a common germicide that you can buy at your pharmacy. It is povidone-iodine solution, the solution doctors use to scrub before surgery.

"Doctors at the Christian Medical College in India performed a study among 40 children with chronic ear infections. Half of the children received 3 drops of povidone-iodine solution in their ears and the other half were given 3 drops of ciprofloxacin eardrops. The dosing was 3 times a day for 10 days. The youngsters were checked every week for 4 weeks. The doctors found both treatments equally effective."8 The benefit of the povidone-iodine solution is that is does not carry the potential problem of drug resistance. This is a treatment for ear infections that you may want to discuss with your child's physician.

We can make a difference in the abatement of drug-resistant bacteria in our environment. By incorporating some of these natural antibiotics and sanitizing agents, we can reduce the risk of infection from drug-resistant bacteria and the proliferation of these germs. Living a clean healthy life has its benefits, beginning with our close nuclear families and reaching out to the global community.

References:

1. Seenivasan Prabuseen, Manickkan Jayakumar, and Saririmuthu lgnicimuthu (No. 30, 2006) "In vitro antibacterial activity of some plant essential oils" BMC Complement Altern Med 6 (39).

2. Carson CF, et al., "Susceptibility of methicillin-resistant Staphylococcus aureus to the essential oil of Melaleuca alternifolia," J Antimicrob Chemother. 1995 Mar;35(3)421-4.

3. Edwards-Jones V, et al., "The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model," Burns. 2004 Dec;30(8):772-7.

4. Nostro A, et al., "Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol," FEMS Microbiol Lett. 2004 Jan 30;230(2)191-5.

5. Preuss HG, et al., "Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria," Mol Cell biocem. 2005 Apr;272(1-2);29-34.

6. Smith-Palmer A, et al., "Influence of subinhibitory concentrations of plant essential oils on the production of enterotoxins A and B and alpha-toxin by Staphylococcus aureus," JMed Microbial. 2004 Oct;53(Pt 10):1023-7.

7. Skocibusic M, Bezic N, "Phytochemical analysis and in vitro antimicrobial activity of two Saturja species essential oils," Phytother Res. 2004 Dec;18(12):967-70.

8. Rosenfeld, T. Dr. Isadore Rosenfeld's 2005 Breakthrough Health.Rodale. 2005. pp 96-98.

Natural Antibiotics Part I: Grapefruit Seed Extract

December 2007

In This Issue

Grapefruit seed extract

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As a health conscious mother (first and foremost) as well as a biochemist with experience in pharmaceutical research, I find this month's topic to be important to many people. I trust that you will find the information on natural antibiotics useful in your life as well.

Sincerely,

Kim Carola
1-800-305-0951

Natural Antibiotics Part I: GSE

Due to the rise in drug resistance, it is now more important than ever to consider natural antibiotic therapies. Physicians are becoming much more conservative in prescribing pharmaceutical antibiotics for common ailments such as ear infections and sore throats. Your doctor may not be well-versed in use of natural antibiotics (or may not feel comfortable suggesting the use of one), but there are some highly effective natural antibiotics that are worth considering. Grapefruit seed extract (GSE) is one such antibiotic with a wide range of uses.

Dr. Allen Sachs, D.C., C.C.N., author of The Authoritative Guide to Grapefruit Seed Extract describes the following criteria of an ideal antibiotic: "It must have broad spectrum application, be powerful and effective, non-toxic, have minimal impact on beneficial bacteria, be well-researched, derived from natural sources, hypo-allergenic, biodegradable, compatible with other natural remedies and affordable." ¹Dr. Sachs states that grapefruit seed extract has proven itself safe and effective for topical and internal use.

Applications of GSE:

The diverse applications of GSE are too numerous to mention in this short article. Here is a small list.

Oral rinse: 3 drops per 5 oz. of water

Toothbrush: 1 drop with or without toothpaste

Facial cleanser: 2-3 drops applied to fingertips and massaged onto a premoistened face.

Skin/nail disorders: 5-10 drops GSE mixed with 1 tablespoon of water applied to affected areas (athlete's foot, insect bites, skin irritations, nail fungus).

Nasal rinse: 1 drop per 1-2 ounces of water. Spray into nostrils with head upright, using eye dropper or nasal sprayer.

Dish/utensil sanitizer: 15-30 drops added to a sink of dishwashing water or to dishwasher.

Laundry sanitizer: 10 drops per small load, 15 drops per large load. (Best results when used in the final rinse.)

Traveler's diarrhea: 3-4 drops per 5 ounces of water taken daily as a preventative.

Toothbrush sanitizer: 5-10 drops per glass of water. (Soak a minimum of 10 minutes.)

Sore throat: 3 drops GSE stirred into 5 ounces of water. Use as a gargle.

Douche: 1-3 drops per 6-8 ounces of water. Douche once a day for one week.

Scalp disorders (dandruff, etc.): 5-10 drops along with regular shampoo. Massage into scalp. Leave it to set a few minutes, then rinse as usual.

Produce/meat/poultry wash: 30 drops per sink full of cold water. To spray wash (10 drops GSE per 32-ounce spray bottle) vegetables, fruits, poultry and meats to extend shelf life.

Cutting board sanitizer: 10-20 drops GSE applied to board after washing using a wet sponge. Let it sit five minutes. Rinse or leave it on without rinsing. Effective against a wide variety of microorganisms including salmonella.

All purpose disinfectant: 30-60 drops GSE per 32-ounce spray bottle mixed with water. Use on sinks, commodes, countertops, fixtures, floors, in wastebaskets or any location that harbors germs.

Research is being done on the efficacy of GSE on viral, fungal and bacterial strains. "GSE researcher William Shannon, Ph.D., cites promising grapefruit seed extract effectiveness in deactivating herpes simplex virus I and influenza type A2 virus. A South American lab satisfactorily tested GSE against measles virus and the USDA determined that four animal viruses (avian influenza, swine vesicular disease, and foot and mouth disease and African swine fever) succumbed to GSE's activity."²

Full strength grapefruit seed extract should be handled cautiously. If direct contact with eyes and skin occurs, one should wash with water.

Impressive results on grapefruit seed extract inactivating numerous types of germs. It is safe, non-toxic, environmentally friendly and it has broad spectrum antimicrobial and germicidal properties. Given its safety and efficacy this natural antibiotic should be considered for use by anyone interested in a natural means of maintaining a clean healthy body and home.

References:

Wellman, T. Total Health. Vol. 24.No. 1 Nov.2002. p.74.

Ibid. p. 78.

Proseed Grapefruit Seed Extract 2 fl. oz.

Grapefruit Seed Extract (GSE) is a broad spectrum antimicrobial compound synthesized in a unique process from the seeds and pulp of grapefruits.

In 1979, Dr. Jacob Harich documented the extraordinary anti-microbial properties of a certain fraction of the seeds and membranous material of grapefruits. Further research by prestigious independent laboratories confirmed its ability to combat a broad range of bacteria, yeast (including candida), parasites, (Amoeba, Giardia, etc.) and even some viruses.