Published scientific studies document that people who eat the most fruits and vegetables have much lower incidences of health problems. Few people, however, consistently eat enough plant foods to protect against common age-related decline,1-3 and commercial multivitamins do not provide all of the vital plant components needed to maintain good health. Life Extension Mix provides concentrations of the fruit and vegetable extracts that researchers have found to be protective against a wide variety of cellular insults.

Life Extension Mix™ contains 92 unique vegetable, fruit, and herbal extracts along with high-potency amino acids, vitamins, minerals, and special antioxidants. The formula is fortified with botanical extracts that help maintain healthy cells via physiological processes separate from traditional antioxidants. Cooking can destroy key nutrients and enzymes in vegetables depleting them of their health benefits. Commercial agriculture processes often result in fruits and vegetables that have not reached maturity and optimal nutrient content. Life Extension Mix provides key compounds found in vegetables and antioxidants found in fruits that are often lost in food production and processing.

Epidemiological studies show that increased intake of polyphenols is associated with a reduced risk of major cardiac events. The ability of cocoa polyphenols to support endothelial function by maintaining healthy nitric oxide levels is the primary protective mechanism. The secondary benefit of suppressing dangerous inflammatory factors is another manner by which cocoa polyphenols may reduce cardiovascular risks.4-8 The Life Extension Mix formula has been upgraded to provide 30 mg of standardized cocoa polyphenols in each daily dose. Based on the research this is the minimum potency of cocoa polyphenols that healthy people will benefit from consuming each day.

Life Extension Mix also contains:

High potency green tea. Life Extension Mix provides 325 mg of a decaffeinated green tea extract that is standardized to contain 98% (318.5 mg) of polyphenols and 45% (146.25 mg) of epigallocatechin gallate EGCG) to which scientists attribute green tea's health benefits.9-15 The amount of polyphenols (including EGCG) in Life Extension Mix is equivalent to drinking 3-6 cups of green tea per day. Scientists have identified multiple mechanisms by which green tea extract protects against LDL oxidation, neuronal oxidation, and a host of other structural and functional age related changes.

Fruit and vegetable extracts

Luteolin is a flavonoid found in parsley, artichoke, basil, celery and other foods. When measured against 27 other flavonoids, luteolin provided the best DNA protection. One favorable mechanism of luteolin is its ability to inhibit oxidative damage to cellular DNA. Another unique benefit is luteolin's ability to suppress excess levels of dangerous inflammatory cytokines such as interleukin-6 and interleukin 1B.16 Life Extension Mix contains a standardized dose of 8 mg luteolin.

Broccoli is touted as one of the most important vegetables to help maintain healthy DNA. Broccoli contains several active constituents, with sulphoraphane being the most significant because of its unique detoxification and DNA protecting effects. Life Extension Mix provides a concentrated broccoli mixture that provides standardized extracts of sulphoraphane and glucosinolates, two compounds attributed to broccoli's multiple protective benefits. Broccoli is also a natural source of gene protecting chlorophyll.*17-21

D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli and Brussels sprouts. D-glucarate effectively supports a detoxification process that helps to remove DNA toxins from the body.22,23 The daily dose of Life Extension Mix provides 200 mg D-glucarate.

Lutein, an extract found in spinach and collard greens, has been shown to help maintain critical pigments in the eye macula, while the carotenoid alpha-carotene has demonstrated antioxidant activity far grater than beta-carotene. Lycopene is the red carotenoid in tomatoes has shown potent effects in helping to maintain healthy DNA structure. Lycopene also protects against LDL oxidation, and aids in maintaining a healthy prostate. Life Extension Mix contains 60 times more lutein and 10 times more lycopene compared to Centrum®. Most multivitamin supplements provide no vegetable extracts.

Life Extension Mix is fortified with fruit extracts such as bilberry, grape seed, grape skin, and citrus bioflavonoids to provide healthy circulation throughout the body and maintain healthy DNA.*

The media has publicized the multiple benefits of fruits such as blackberry, cranberry, elderberry, cherry, plums and persimmon. Life Extension Mix has a customized blend of these and other fruits that studies indicate provide multiple favorable effects in the body.

Pomegranate extract standardized to provide the punicalagins and other polyphenols found in up to 2.6 ounces of pomegranate juice.

Wild blueberry extract, concentrated and standardized, has been added to provide optimal beneficial effects.

Olive oil consumption is one of the important factors behind the health benefits of the "Mediterranean Diet."24,25 Researchers have discovered that there are up to 300 times more polyphenol compounds in olive water compared to olive oil.26,27 Olive polyphenols have been the subject of numerous studies pointing toward their benefits in many different areas, including helping to protect against LDL oxidation, suppressing free radicals, and stabilizing cell membranes.28-30 Life Extension Mix contains a potent olive juice extract standardized to contain 7 percent of the best-documented polyphenol called hydroxytyrosol.31 The amount of hydroxytyrosol in Life Extension Mix is equivalent to drinking one ounce of virgin olive oil per day.32-33

Sesame lignans enhance the effects of vitamin E. Sesame and its lignans have a broad range of applications in human health. This includes increasing human tissue levels of vitamin E by facilitating carrier proteins in the liver to deliver nutrients to cells throughout the body.34,35

Sesame lignans increase the anti-inflammatory index of fish oils and help maintain healthy cholesterol/LDL levels in those already within normal range.*36-39 Life Extension Mix contains 10 mg sesame lignan extract to provide the direct benefits of the lignans and augment the effects of vitamin E and other nutrients in the body such as gamma-tocopherol and gamma-linolenic acid (GLA).

Vitamins

Pyridoxal 5-phosphate helps protect against glycation reactions, a toxic process by which sugars bind to proteins to form nonfunctional structures in the body.

High potency vitamin D3: Doctors used to be concerned that too much vitamin D could be toxic. Over the past few years, however, an increasing body of evidence indicates that it takes much higher doses of vitamin D (perhaps over 10,000 IU/day) to result in toxicity in a healthy person. The concern expressed by researchers today is that fear of vitamin D toxicity is keeping many people from supplementing with enough vitamin D, which is critical for maintaining bone density. In response to studies showing that even those who take standard vitamin D supplements are not obtaining adequate amounts, Life Extension Mix provides 800 IU vitamin D3 per daily dose.

Life Extension Mix™ contains only the dry powder form of vitamin E. This natural form of vitamin E (succinate) has been shown to promote healthy DNA better than other forms.

Amino Acids

N-acetyl-cysteine suppresses free radicals inside the cells and maintains healthy glutathione levels. Taurine may protect against free radicals between cells and supports eye health.

Minerals

Some scientific evidence suggests that consumption of selenium may reduce the risk of certain forms of cancer; however, the FDA has determined that this evidence is not conclusive.

Zinc is often poorly absorbed, but Life Extension Mix™ provides two of the most bioavailable forms of zinc.

Boron is not only needed to maintain healthy bone density, but may also help promote healthy prostate cell development.

Chromium: Life Extension Mix contains a superior and biologically active trivalent chromium complex, a unique food form bio-organic water soluble matrix. Chromium, along with magnesium and biotin, are nutrients required to maintain healthy blood sugar levels in those already within normal range.40,41

Higher potency magnesium: Magnesium is needed for more than 300 biochemical reactions in the body. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, supports a healthy immune system, and keeps bones strong. Magnesium also helps maintain healthy blood sugar and blood pressure levels in those already within normal range, and is known to be involved in energy metabolism and protein synthesis.

Cholinergic nutrients

Maintaining high levels of acetylcholine in the brain by consuming choline helps correct mild memory problems associated with aging and helps protect against age-associated mental decline.

Life Extension Mix saves time and money by combining the most popular nutrient supplements in one product, eliminating the need to take separate bottles of B-complex, vitamins C and E, mineral supplements and much more that would be required to achieve the same effects. Life Extension Mix supplies the most powerful antioxidants, including water and fat soluble vitamin C, the ideal form of alpha vitamin E, and plant extracts that help protect against cellular DNA damage. Other ingredients in Life Extension Mix enhance beneficial DNA methylation patterns, and help maintain glycemic control and healthy levels of LDL in those already within normal range. Life Extension uses standardized herbal extracts to ensure that our products contain the highest level of biological activity.

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9. Fassina G, Vene R, Morini M et al, Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate. Clin Cancer Res. 2004; 10(14):4865-73.
10. Yang CS, Chung JY, Li C et al. Mechanisms of inhibition of carcinogenesis by tea. Biofactors 2000;13:91-4):73-9.
11. Fujiki, H. Two stages of cancer prevention with green tea. J Cancer Res Clin Oncol 1999 Nove;125(11):589-97.
12. Xu JZ, Yeung SY, Chang Q et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br J Nutr. 2004 Jun;91(6):873-81.
13. Miyazawa T. Absorption, metabolism and antioxidative effects of tea catechins in humans. Biofactors 200;13(1-4):55-9.
14. Xie D, Liu G, Ghu G et al. [-]-Epigallocatechin-3-gallate protects cultured spiral ganglion cells from H2O2-induced oxidizing damage. Acta Otolaryngol. 2004 May;124(4):464-70.
15. Beliveau R, Gingras D. Green tea prevention and treatment of cancer by nutriceuticals. Lancet 2004 Sep 18;364(9439):1021-2.
16. Kotanidou A. Luteolin reduces lipolysaccharide-induced lethal toxicity and expression of proinflammatory molecules in mice. Am J Respir Crit Care Med, 2003 Mar 15;165(6):818-23.
17. Zhang Y, Callaway ED. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J. 2002 May 15:364(Pt 1):301-7.
18. Faulkner K, Mithen R. et al. Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl gluosinolate in broccoli. Carcinogenesis. 1998 Apr;19(4):605-9.
19. Vang O, Frandsen H, et al. Biochemical effects of dietary intakes of different broccoli samples. I. Differential modulation of cytochrome P-450 activities in rat liver, kidney, and colon. Metabolism. 2001 Oct;50(10):1123-9.
20. Vang O, Mortensen J, et al. Biochemical effects of dietary intake of different broccoli samples. II. Multivariate analysis of contributions of specific glucosinolates in modulating cytochrome P-450 and antioxidant defense enzyme activities. Metabolism. 2001 Oct;50(10):1130-5.
21. Smith TK, Mithen R, Johnson IT. Effects of brassica vegetable juice on the induction of apoptosis of aberrant crypt foci in rat colonic mucosal crypts in vivo. Carcinogenesis 2003 Mar;24(3):491-5.
22. Hanausek M, Walaszek A, Slaga TJ. Detoxifying cancer causing agents to prevent cancer. Integr Cancer Ther. 2003 Jun;2(2):139-44.
23. Walaszek Z, Szemjaf J, Narag M et al. Metabolism, uptake and excretion of a D-glucaric acid salt and potential use in cancer prevention. Cancer Detect Prev. 997;21(2):178-90.
24. Visioli F, Galli C. Biological properties of olive oil phytochemicals. Cri Rev Food Sci Nutri. 2002; 42(3):209-21.
25. Valavanidis A, Nisiotou C, Papageoriou Y et al. Comparison of the radical scavenging potential of polar and lipidic fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21;52(8):2358-65.
26. Ranalli A, Lucer L, Contento S. Antioxidizing potency of phenol compounds in olive mill wastewater. J Agric Food Chem. 2003 Dec 17;51(26):7636-41.
27. Water-soluble olive polyphenols. Technical file, Inosud S.A. Groupe La Gardonnenque, updated 31/01/2003.
28. Valavanidis A, Nisiotou C, Papageoriou Y et al. Comparison of the radical scavenging potential of polar and lipid fractions of olive oil and other vegetable oils under normal conditions and after thermal treatment. J Agric Food Chem. 2004 Apr 21:52(8):2358-65.
29. Carluccio MA, Sicuella L, Ancora MA et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thrmob Vasc Biol. 2003 Apr 1;23(4):622-9.
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32. Haban P, Klvanova J, Zidekova E et al. Dietary supplementation with olive oil leads to improved lipoprotein spectrum and lower n-6 PUFAs in elderly subjects. Med Sci Monit. 2004 Apr;10(4):PI49-54.
33. Vissers MN, Zock PL, Katan MB. Bioavailability and antioxidant effects of olive oil phenols in humans--a review. Eur J Clin Nutr. 2004 June;58(6):955-65.
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Dosage and Use

• Fourteen capsules per day in divided doses with meals.

• The niacin in this product may cause flushing (a feeling of warmth and reddening of the skin). This effect is temporary and harmless.

• Refrigeration is recommended.

Warnings

• Keep out of reach of children.

• Do not exceed recommended dose.

• If you have a bad reaction to this product, discontinue use.

• When using nutritional supplements, please inform your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.